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Imaging the early response to treatment in patients with interstitial pneumonia with dual-time-point 18F-FDG PET imaging

Research Project

Project/Area Number 26860990
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionUniversity of Fukui

Principal Investigator

Umeda Yukihiro  福井大学, 医学部附属病院, 助教 (80401975)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords特発性間質性肺炎 / 治療効果判定 / FDG / PET / 間質性肺炎 / FDG-PET / 2時相FDG-PET / 無増悪生存期間
Outline of Final Research Achievements

The aim of this prospective study was to clarify whether dual-time-point 18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent 18F-FDG PET examinations at 2 time points. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated. Results: A multivariate Cox proportional hazard model showed higher RI-SUV as independent predictors of shorter PFS. On the other hand, multivariate Cox analysis showed higher RI-SUV to be independent predictors of shorter overall survival. In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality. Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Prognostic value of dual-time-point [18F]-2-fluoro-2-deoxyglucose PET for idiopathic pulmonary fibrosis.2015

    • Author(s)
      Umeda Y, Demura Y, Morikawa M, Anzai M, Kadowaki M, Ameshima S, Tsuchida T, Tsujikawa T, Kiyono Y, Okazawa H, Ishizaki T, Ishizuka T.
    • Journal Title

      J Nucl Med

      Volume: 56 Issue: 12 Pages: 1869-1875

    • DOI

      10.2967/jnumed.115.163360

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 特発性肺線維症の生命予後予測におけるdual-time-point 18F-FDG PET画像の有用性2015

    • Author(s)
      梅田幸寛、園田智明 、山口牧子1、本定千知 、酒井啓行 、森川美羽門、脇麻衣子、安齋正樹、飴嶋慎吾、岡沢秀彦、石﨑武志、石塚 全
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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