Imaging the early response to treatment in patients with interstitial pneumonia with dual-time-point 18F-FDG PET imaging

• Project/Area Number: 26860990
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: Umeda Yukihiro 福井大学, 医学部附属病院, 助教 (80401975)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 特発性間質性肺炎 / 治療効果判定 / FDG / PET / 間質性肺炎 / FDG-PET / 2時相FDG-PET / 無増悪生存期間

Outline of Final Research Achievements

The aim of this prospective study was to clarify whether dual-time-point 18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent 18F-FDG PET examinations at 2 time points. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated. Results: A multivariate Cox proportional hazard model showed higher RI-SUV as independent predictors of shorter PFS. On the other hand, multivariate Cox analysis showed higher RI-SUV to be independent predictors of shorter overall survival. In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality. Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.

Research Products

• [Journal Article] Prognostic value of dual-time-point [18F]-2-fluoro-2-deoxyglucose PET for idiopathic pulmonary fibrosis. (2015)
  • Author(s): Umeda Y, Demura Y, Morikawa M, Anzai M, Kadowaki M, Ameshima S, Tsuchida T, Tsujikawa T, Kiyono Y, Okazawa H, Ishizaki T, Ishizuka T.
  • Journal Title: J Nucl Med Volume: 56 Issue: 12 Pages: 1869-1875
  • DOI: 10.2967/jnumed.115.163360
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 特発性肺線維症の生命予後予測におけるdual-time-point 18F-FDG PET画像の有用性 (2015)
  • Author(s): 梅田幸寛、園田智明 、山口牧子1、本定千知 、酒井啓行 、森川美羽門、脇麻衣子、安齋正樹、飴嶋慎吾、岡沢秀彦、石﨑武志、石塚 全
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17