| Project/Area Number |
26860990
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
Umeda Yukihiro 福井大学, 医学部附属病院, 助教 (80401975)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 特発性間質性肺炎 / 治療効果判定 / FDG / PET / 間質性肺炎 / FDG-PET / 2時相FDG-PET / 無増悪生存期間 |
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| Outline of Final Research Achievements |
The aim of this prospective study was to clarify whether dual-time-point 18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent 18F-FDG PET examinations at 2 time points. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated. Results: A multivariate Cox proportional hazard model showed higher RI-SUV as independent predictors of shorter PFS. On the other hand, multivariate Cox analysis showed higher RI-SUV to be independent predictors of shorter overall survival. In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality. Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.
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