| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The purpose of this study is to establish a novel internal radiotherapy using thermo-responsive polymers under mild hyperthermia. We newly designed and synthesized non-radiolabeled and radiolabeled polyoxazoline (POZ) derivatives, and evaluated the physicochemical property and in vivo biodistribution in colon26 tumor-bearing mice. We demonstrated that POZ with ethyl and isopropyl groups in side chains (Et-Isp-POZ) had a transition temperature of 39℃ and showed rapid aggregation. Moreover, In-111-labeled Et-Isp-POZ demonstrated a modest tumor uptake and a rapid clearance from normal tissues in tumor-bearing mice. In the future, we will investigate the tumor uptake of In-111-labeled Et-Isp-POZ under mild hyperthermia.
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