Development of [18F]FBPA new labeling synthesis method for the spread of Boron Neutron Capture Therapy

Research Project

Project/Area Number	26860994
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Osaka University
Principal Investigator	Naka Sadahiro 大阪大学, 医学部附属病院, 薬剤師 (60599843)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	PET / BNCT / FBPA / PET薬剤
Outline of Final Research Achievements	We tried to develop a novel synthesis of [18F] FBPA for PET inspection to determine the implementation propriety of Boron Neutron Capture Therapy, aimed to improve the inspection number.We compared with the conventional method for solubility in various solvents and it's labeling index using a novel precursor. As a result, the Boc-BPA-tBu was almost unreacted in all solvents. But we were able to establish a process to de-protection from the label in the present study.In the Cbz-BPA, labeling index of the target was about 35% before de-protection.It was about the same as the labeling index of the conventional method.

Report

(3 results)