Understanding the brain pathology with individual immune cell tracking using high-field MRI scanner
Project/Area Number |
26860996
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Osaka University |
Principal Investigator |
Mori Yuki 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (10559355)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 磁気共鳴画像法 / 免疫細胞動態 / 細胞追跡 / 神経免疫 |
Outline of Final Research Achievements |
We established highly sensitive in-vivo imaging techniques for sequential monitoring of intrinsic monocytes/macrophages migration in the mouse brain at the single-cell level by using 11.7T high-field magnetic resonance imaging (MRI) scanner. We have successfully improved the spatio-temporal resolution of MRI for cellular tracking and created a 4D cellular tracking dataset of intrinsic monocytes/macrophages in the living mouse brain. In addition, we conducted quantitative analysis of individual cells using this dataset. In this procedure, we found a significant difference in velocity and migration patterns between the contralateral and the ipsilateral cortex in the mouse stroke model.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties2016
Author(s)
Yoshimasa Makita, Masashi Inoue, Natsuki Katayama, Hsien-Han Lee, Taro Abe, Chizuko Inui-Yamamoto, Yuki Mori, Yoshichika Yoshioka, Yoshitomo Honda, Shoko Gamoh, Kimishige Shimizutani, Shin-ichi Fujiwara, Akiya Ogawa
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Journal Title
Polyhedron
Volume: 107
Pages: 148-152
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model2015
Author(s)
Arima, Y., D. Kamimura, T. Atsumi, M. Harada, T. Kawamoto, N. Nishikawa, A. Stofkova1, T. Ohki, K. Higuchi, Y. Morimoto, P. Wieghofer, Y. Okada, Y. Mori, S. Sakoda, S. Saika, Y. Yoshioka, I. Komuro, T. Yamashita, T. Hirano, M. Prinz, M. Murakami.
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Journal Title
eLife
Volume: 4
Pages: 1-23
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] From cartoon to real time MRI: in vivo monitoring of phagocyte migartion in mousse brain2014
Author(s)
Mori, Y., Chen, T., Fujisawa, T., Kobashi, S., Ohno, K., Yoshida, S., Tago, Y., Komai, Y., Hata, Y. and Yoshioka, Y.
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Journal Title
Scientific Reports
Volume: 4
Issue: 1
Pages: 6997-6997
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A short-wavelength infrared emiting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice2014
Author(s)
Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y. and Jin, T.
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Journal Title
Chemical Communication
Volume: 50
Issue: 92
Pages: 14356-14359
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Diffusion tensor imaging of barin abnormalities induced by prenatal exposure to radiation in rodents2014
Author(s)
Saito, S., Sawada, K., Hirose, M., Mori, Y., Yoshioka, Y. and Murase, K.
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Journal Title
PLoS ONE
Volume: 9 (9)
Issue: 9
Pages: e107368-e107368
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria.2014
Author(s)
H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
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Journal Title
Cell Host Microbe
Volume: 15
Issue: 5
Pages: 551-563
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Tri-modal imaging techniques Cathodoluminescence (CL) - Near Infrared (NIR) and Magnetic resonance imaging (MRI) with lanthanides doped Gd2O32015
Author(s)
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Masayoshi Ichimiya, Masaaki Ashida, Yuki Mori , Yoshichika Yoshioka, Mamoru Hashimoto, Jun Miyake
Organizer
The 2nd East-Asia Microscopy Conference
Place of Presentation
Himeji, Hyogo
Year and Date
2015-11-24
Related Report
Int'l Joint Research
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[Presentation] SPIOを用いたループス腎炎の評価2015
Author(s)
陳挺, 森勇樹, 程振宇, Soyoung Lee, Barry Ripley, 岸本忠三, 乾千珠子, 多 胡善幸,吉田慎一, 大野工司, 吉岡芳親
Organizer
第43回日本磁気共鳴医学会大会
Place of Presentation
東京
Year and Date
2015-09-10
Related Report
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[Presentation] Visualization of lupus nephritis using SPIO2015
Author(s)
T Chen, Y Mori, Z Cheng, S Lee, K Wang, B Ripley, T Kishimoto, C Inui-Yamamoto, F Sugihara, N Kitagaki, Y Tago, S Yoshida, K Ohno, Y Yoshioka
Organizer
Annual Meeting of ISMRM
Place of Presentation
Toronto, Canada
Year and Date
2015-06-01
Related Report
Int'l Joint Research
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[Presentation] New magnetic nanoparticle for kidney function2015
Author(s)
Ting Chen, Yuki Mori, Chizuko Inui-Yamamoto, Ikuhiro Kida, Yoshichika Yoshioka
Organizer
International Symposium "Neural Mechanisms of Vision and Cognition"
Place of Presentation
Center for Information and Neural Networks (Osaka)
Year and Date
2015-03-02 – 2015-03-03
Related Report
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[Presentation] In vivo MRI monitoring of inflammatory alterations and cellular dynamics in the central nervous system2014
Author(s)
Yuki Mori, Yasunobu Arima, Ting Chen, Dasong Zhu, Tetsuya Fujisawa, Shoji Kobashi, Yutaka Komai, Masaaki Murakami, Yutaka Hata, Yoshichika Yoshioka
Organizer
World Automation Congress
Place of Presentation
Waikoloa, HI, US
Year and Date
2014-08-03 – 2014-08-07
Related Report
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[Presentation] Sequential and Time-Lapse MRI Monitoring of Peripheral Macrophage Recruitment and Migration in Mouse Brain2014
Author(s)
Yuki Mori, Ting Chen, Kohji Ohno, Shinichi Yoshida, Yoshiyuki Tago, Tetsuya Fujisawa, Yuto Kashiwagi, Masaki Fukunaga, Yutaka Komai, Yutaka Hata, Yoshichika Yoshioka
Organizer
Joint Annual Meeting ISMRM-ESMRMB
Place of Presentation
Milan, Italy
Year and Date
2014-05-10 – 2014-05-16
Related Report
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[Presentation] New Magnetic Nanoparticle for Kidney Function2014
Author(s)
Yoshichika Yoshioka, Ting Chen, Yuki Mori, Zhenyu Cheng, Yuto Kashiwagi, Masaki Fukunaga, Ikuhiro Kida, Yoshiyuki Tago, Shinichi Yoshida, Kohji Ohno
Organizer
Joint Annual Meeting ISMRM-ESMRMB
Place of Presentation
Milan, Italy
Year and Date
2014-05-10 – 2014-05-16
Related Report
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