Development of a novel radiotherapy method for pancreatic cancer by using antioxidant and absorbable spacer to protect an intestinal canal.
Project/Area Number |
26860997
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 放射線治療 / 放射線防護 / 膵がん / スペーサー / 還元型CoQ10 / 粒子線治療 / 腸管防護 |
Outline of Final Research Achievements |
Radiotherapy for pancreatic cancer is difficult to deliver curative dose because of risk organs surrounded pancreas. To overcome this problem, we developed a novel radiotherapy method using a novel absorbable spacer. And, we also confirmed the radioprotective effect using Reduced CoQ10. From our experiments, a novel spacer can reduce the radiation damage of intestine, and Reduced CoQ10 can suppress the generation of apoptosis induced by radiation in the intestine. As a result, the survival rate of an experimental animal in this study was improved.
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Report
(3 results)
Research Products
(10 results)
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[Presentation] Next-stage Bioabsorbable Spacer in Particle Therapy2015
Author(s)
T.Y. Wang, Hiroaki Akasaka, Yasuo Ejima, Kenji Yoshida,Daisuke Miyawaki,Takeaki Ishihara,Naritoshi Mukumoto,Takumi Fukumoto,Ryohei Sasaki
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto, Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] A Novel method of Radioprotection for the Gastointestinal System: Efficacy of the reduced form of Coenzyme Q102015
Author(s)
Saki Osuga, Naritoshi Mukumoto, Nelly Binti Idrus, Ray Uchida, Hiroaki Akasaka, Daisuke Miyawaki, Yoshiro Matsuo, Yasuo Ejim, Mitsuaki Kitano, Hiroshi Kubo, Hideyuki Kishida, Takahiro Yasuda, Ryohei Sasaki
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto, Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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[Presentation] Efficacy of PGA Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs2014
Author(s)
H Akasaka, R Sasaki, D Miyawaki, N Mukumoto, NS Sulaiman, TY Wang, S Yamada, M Murakami, Y Demizu, T Fukumoto
Organizer
MMND & IPCT 2014
Place of Presentation
Port Douglas, Australia
Year and Date
2014-10-20 – 2014-10-25
Related Report
Invited
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[Presentation] A Novel Radiosensitizer, Monogalactosyl diacylglycerol, Enhanced the Cytotoxic Effects for the Pancreatic Cancer2014
Author(s)
H Akasaka, R Sasaki, I Takayama, M Nakahana, NS Sulaiman, D Miyawaki, K Yoshida, Y Ejima, H Uezono, Y Mizushina
Organizer
European Society for Radiotherapy & Oncology 33
Place of Presentation
Vienna, Austria
Year and Date
2014-04-04 – 2014-04-08
Related Report
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[Book] NON-WOVEN FABRICS2016
Author(s)
Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang and Takumi Fukumoto
Total Pages
10
Publisher
InTech
Related Report