Response of radiation resistance tumor to micro-slit beam high-dose radiation therapy

• Project/Area Number: 26860998
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: MUKUMOTO Naritoshi 神戸大学, 医学部附属病院, 特命技術員 (70634278)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マイクロビーム / 放射線治療 / SPring-8 / 放射光 / 耐容線量 / マイクロビームX線 / 正常組織耐容線量

Outline of Final Research Achievements

Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in a single fraction using arrays of microplanar X-ray beams. Microplanar beam (MPB) radiation is, at present, an experimental approach that has produced, in single exposures, exceptionally high tolerance in the normal tissues while preferentially damaging malignant tumors.

Research Products

• [Presentation] Response of multiple lung-metastatic tumor to microplanar beam irradiation (2015)
  • Author(s): Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Ray Cory Uchida, Keiji Umetani, Nobuteru Nariyama, Takeaki Ishihara, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima and Ryohei Sasaki
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: 群馬
  • Year and Date: 2015-11-19
• [Presentation] Tolerance for Micro-slit beam X-ray radiation to Central Nervous System (2015)
  • Author(s): Naritoshi Mukumoto, Hiroaki Akasaka, Masao Nakayama, Yasushi Miura, Daisuke Miyawaki, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh and Ryohei Sasaki
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] A Novel Metallic Eye Shield for Electron Treatment in Eyelid Skin Cancer: A Dosimetric Study (2014)
  • Author(s): N Mukumoto, T Minami, D Miyawaki, N Yoshida, H Akasaka, H Uezono, Y Ejima, Y Aoyama, R Sasaki
  • Organizer: The 15th Asian Oceanian Congress of Radiology AOCR 2014
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] 放射光マイクロビームＸ線を用いた放射線抵抗性腫瘍に対する超高線量率 放射線治療の検討 (2014)
  • Author(s): 椋本 成俊
  • Organizer: 近畿がん診療推進ネットワーク設立3周年記念講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-21