| Project/Area Number |
26861000
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
NAKAYAMA MASAO 神戸大学, 医学(系)研究科(研究院), 医学研究員 (60582004)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 放射線治療 / ナノ粒子 / チタン酸化物 / 活性酸素種 / 放射線増感 / 放射線増感剤 |
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| Outline of Final Research Achievements |
The efficacy of titanium peroxide nanoparticles (TiOxNPs) made from titanium dioxide in cancer therapy was investigated. The TiOxNPs showed a distinct ability to produce reactive oxygen species (ROS) upon X-ray irradiation in a dose- and concentration-dependent manner. TiOxNPs conjugated to polyacrylic acid (PAA-TiOxNPs) were stable for in vitro and in vivo study. The absorption of PAA-TiOxNPs enhanced DNA damage and resulted in higher cytotoxicity in response to X-ray irradiation in vitro. Growth inhibition of the tumor in the combination of PAA-TiOxNP and X-ray irradiation was significantly greater than single treatment subgroups in vivo. No apparent toxicity or weight loss was observed for 43-day observation period after irradiation. This study demonstrates that TiOxNPs have a potential to be a safe and distinct radiosensitizers for cancer therapy through the production of ROS.
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