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Next-generation sequencing approach to detect chemoradiotherapy response in esophageal cancer

Research Project

Project/Area Number 26861003
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

Hirata Hidenari  九州大学, 大学病院, その他 (90721267)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords化学放射線感受性 / 遺伝子異常 / 食道癌 / エキソームシークエンス / RNAシークエンス / メチル化シークエンス / 化学放射線治療 / CRT / 食道扁平上皮癌
Outline of Final Research Achievements

Esophageal Squamous Cell Carcinoma(ESCC) is resistant to chemoradiotherapy (CRT); therefore, identification of useful biomarkers predicting CRT response is required. To determine whether gene alterations associate with response to CRT, next-generation sequencingt of ESCC treated with definitive CRT was performed. We carried out whole-exome sequencing, DNA methylation sequencing, and RNA sequencing of 6 pretreatment and 2 recurrent ESCCs. Then, gene alterations of CRT responders were compared with CRT nonresponders. We found that the presence of TP53 mutation could not predict clinical response to CRT. We will analyze in detail for genome, epigenome and transcriptome profiles of ESCC treated with definitive CRT.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma2016

    • Author(s)
      Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
    • Journal Title

      Cancer Res.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.2016

    • Author(s)
      G. Sawada (他43名, 山本21番目)
    • Journal Title

      Gastroenterology

      Volume: 150 Issue: 5 Pages: 1171-1182

    • DOI

      10.1053/j.gastro.2016.01.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.2016

    • Author(s)
      R. Uchi (他40名, 山本36番目)
    • Journal Title

      PLoS Genetics

      Volume: 12 Issue: 2 Pages: 1-24

    • DOI

      10.1371/journal.pgen.1005778

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma2015

    • Author(s)
      Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Yamasaki M, Tanaka F, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Tanaka Y, Calin G, Miyano S, Doki Y, Mori M, Mimori K
    • Journal Title

      PLoS One

      Volume: 10(10) Issue: 10 Pages: e0139808-e0139808

    • DOI

      10.1371/journal.pone.0139808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics and outcome of pneumothorax after stereotactic body radiotherapy for lung tumors.2015

    • Author(s)
      Asai K, Nakamura K, Shioyama Y, Sasaki T, Matsuo Y, Ohga S, Yoshitake T, Terashima K, Shinoto M, Matsumoto K, Hirata H, Honda H.
    • Journal Title

      Int J Clin Oncol

      Volume: epub Issue: 6 Pages: 1117-21

    • DOI

      10.1007/s10147-015-0833-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma.2014

    • Author(s)
      Hirata H, Sugimachi K, Takahashi Y, Ueda M, Sakimura S, Uchi R, Kurashige J, Takano Y, Nanbara S, Komatsu H, Saito T, Shinden Y, Iguchi T, Eguchi H, Atsumi K, Sakamoto K, Doi T, Hirakawa M, Honda H, Mimori K.
    • Journal Title

      Ann Surg Oncol.

      Volume: epub Issue: S3 Pages: 1402-9

    • DOI

      10.1245/s10434-014-4242-0

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of CDCP1 expression promotes invasiveness and poor prognosis in esophageal squamous cell carcinoma.2014

    • Author(s)
      Sawada G, Takahashi Y, Niida A, Shimamura T, Kurashige J, Matsumura T, Ueo H, Uchi R, Takano Y, Ueda M, Hirata H, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Miyano S, Doki Y, Mori M, Mimori K.
    • Journal Title

      Ann Surg Oncol.

      Volume: 4 Issue: S4 Pages: 640-647

    • DOI

      10.1245/s10434-014-3740-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Fructose-1,6-biphosphatase発現異常は肝癌の腫瘍進展・糖代謝異常に寄与する2016

    • Author(s)
      平田 秀成、杉町 圭史、増田 隆明、林 直樹、井口 友宏、江口 英利、伊藤修平、寺嶋 広太郎、坂本 勝美、平川 雅和、本田 浩、三森 功士
    • Organizer
      第18回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2016-02-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食道発癌・癌進展の宿主側・腫瘍側・疫学環境要因からの三位一体の解明2015

    • Author(s)
      平田秀成、三森功士
    • Organizer
      がんゲノム・エピゲノムセミナー
    • Place of Presentation
      花巻
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] FBP1 suppresses tumor progression and retrieves altered glucose metabolism in Hepatocellular carcinoma2015

    • Author(s)
      Hirata H, Sugimachi K, Komatsu H, Ueda M, Uchi R, Sakimura S, Masuda T, Iguchi T, Eguchi H, Ito S, Hirakawa M, Honda H, Mimori K.
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comprehensive Mutation Analysis of Response to Chemoradiothrapy in Esophageal Squamous Cell Carcinoma.2015

    • Author(s)
      H Hirata, R Uchi, M Ueda, S Sakimura, Y Shinden, T Iguchi, K Atsumi, D Tsurumaru, K Sakamoto, K Sugimachi, M Hirakawa, T Sasaki, K Nakamura, H Honda, K Mimori.
    • Organizer
      15th International Congress of Radiation Research
    • Place of Presentation
      京都
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エキソームシークエンスによる食道癌化学放射線感受性の多様性を規定する網羅的変異解析2015

    • Author(s)
      平田秀成、内龍太郎、上田正射、﨑村正太郎、小松久晃、南原翔、齋藤衆子、新田吉陽、井口友宏、江口英利、杉町圭史、渥美和重、坂本一美、平川雅和、本田浩、三森功士
    • Organizer
      第17回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2015-02-02 – 2015-02-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Mutational Analysis of Peritoneal Disseminated Model in Gastric Adenocarcinoma2014

    • Author(s)
      Hirata H, Kurashige J, Sugimachi K, Uchi R, Ueda M, Sakimura S, Takano Y, Shinden Y, Iguchi T, Eguchi H, Hirakawa H, Honda H, Mimori M.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 放射線腫瘍医として知っておきたい分子標的治療 -放射線治療との併用を中心に-2014

    • Author(s)
      平田秀成
    • Organizer
      第26回九州放射線治療セミナー
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-09 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Down-regulation of PRRX1 confers cancer stem cell-like properties and poor prognosis in hepatocellular carcinoma2014

    • Author(s)
      Hirata H, Sugimachi K, Uchi R, Kurashige J, Matsumura T, Ueo H, Takano Y, Ueda M, Sakimura S, Shinden Y, Eguchi H, Sudo T, Hirakawa M, Honda H, Mimori M.
    • Organizer
      The 105th Annual Meeting of the American Association for Cancer Research
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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