| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To evaluate the histopathological features of experimental aneurysms embolized with bare platinum, fibered, and bioactive coils,respectively.Sixteen experimental aneurysms were constructed in four swine. Aneurysms were divided into three groups embolized using bare platinum coil alone (P group, n = 4), bioactive coil alone (B group, n = 4), and a combination of fibered and bioactive coils (F/B group, n = 8). Histopathological data for all aneurysms were analyzed. Neointima thickness was significantly greater in the F/B group compared with the P group (P = 0.038).Inflammation with foreign-body giant-cell infiltration was significantly greater in the F/B group compared with P and B groups .Embolization of experimental aneurysms with bare platinum, fibered, and bioactive coils is associated with different histopathological features. Use of combined fibered and bioactive coils is associated with greater neointima formation and more foreign-body giant-cell infiltration.
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