Development of the new radiosensitizer which targetted nuclear DNA by the PI polyamide

• Project/Area Number: 26861021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nihon University
• Principal Investigator: ISHIBASHI Naoya 日本大学, 医学部, 助教 (40649331)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 放射線増感剤 / ヨード化PIポリアミド / 白金PIポリアミド

Outline of Final Research Achievements

The existent radiosensitizer has a problem such as low of the selectivity and the specificity to the tumor cell and the side effect by cell toxicity. We planned to combine the PI polyamide with an iodine, and this iodine labeled PI polyamide might be a new radiosensitizer which selectivity combined with nuclear DNA and reduce the toxicity.