The development of a novel imaging diagnostic system for the dementia with lewy bodies: application of high definition imaging technique

• Project/Area Number: 26861022
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa Medical University
• Principal Investigator: OKUDA Koichi 金沢医科大学, 一般教育機構, 講師 (60639938)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 核医学 / 線条体 / デジタルファトム / シミュレーション / イメージング / デジタルファントム / DATイメージング / 高解像度 / XCAT / モンテカルロシミュレーション / SIMIND / 核医学イメージング / SPECT / Planar / I-123 / 画像処理 / ドーパミントランスポーター / 分子イメージング

Outline of Final Research Achievements

The aim of this study was to develop the high definition technique for the dopamine transporter (DAT) imaging. Since the degradation of a DAT image by the high-energy gamma ray is expressed as a mathematical equation, the effect of high-energy gamma ray can be estimated using this equation. The striatal phantom imaging was performed using the low-energy general-all-purpose (LEGAP) and Fan-beam collimators, and imaging characteristics for two collimators was determined. Moreover, we performed simulation study using a digital phantom and Monte Carlo simulation code.

Research Products

• [Journal Article] Cardiac and Respiratory Motion-induced Artifact in Myocardial Perfusion SPECT (2017)
  • Author(s): Okuda Koichi、Nakajima Kenichi、Kikuchi Akihiro、Onoguchi Masahisa、Hashimoto Mitsumasa
  • Journal Title: Annals of Nuclear Cardiology Volume: 3 Issue: 1 Pages: 88-93
  • DOI: 10.17996/anc.17-00005
  • NAID: 130006191141
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed / Open Access
• [Journal Article] Normal Values and Gender Differences of Left Ventricular Functional Parameters with CardioREPO Software (2017)
  • Author(s): Koichi Okuda, Kenichi Nakajima
  • Journal Title: Annals of Nuclear Cardiology Volume: 3 Issue: 1 Pages: 29-33
  • DOI: 10.17996/anc.17-00004
  • NAID: 130006191140
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT (2017)
  • Author(s): Okuda Koichi、Nakajima Kenichi、Matsuo Shinro、Kashiwaya Soichiro、Yoneyama Hiroto、Shibutani Takayuki、Onoguchi Masahisa、Hashimoto Mitsumasa、Kinuya Seigo
  • Journal Title: EJNMMI Research Volume: 7 Issue: 1 Pages: 27-27
  • DOI: 10.1186/s13550-017-0274-3
  • Peer Reviewed / Open Access
• [Journal Article] Creation and characterization of normal myocardial perfusion imaging databases using the IQ・SPECT system. (2017)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Chisato Kondo, Masayoshi Sarai, Yoriko Horiguchi, Takahiro Konishi, Masahisa Onoguchi, Takeshi Shimizu, Seigo Kinuya.
  • Journal Title: J Nucl Cardiol Volume: 印刷中 Issue: 4 Pages: 1-10
  • DOI: 10.1007/s12350-016-0770-2
  • Peer Reviewed
• [Journal Article] Development and validation of a direct-comparison method for cardiac I-123 metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging. (2016)
  • Author(s): Okuda K, Nakajima K, Sugino S, Kirihara Y, Matsuo S, Taki J, Hashimoto M, Kinuya S.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 2 Pages: 319-325
  • DOI: 10.1007/s00259-015-3173-8
  • Peer Reviewed / Open Access
• [Journal Article] The time has come to standardize (123)I-MIBG heart-to-mediastinum ratios including planar and SPECT methods. (2016)
  • Author(s): Nakajima K, Okuda K, Matsuo S, Agostini D.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 2 Pages: 386-388
  • DOI: 10.1007/s00259-015-3258-4
  • NAID: 120005890406
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Influence of ROI definition on the heart-to-mediastinum ratio in planar 123I-MIBG imaging. (2016)
  • Author(s): Klene C, Jungen C, Okuda K, Kobayashi Y, Helberg A, Mester J, Meyer C, Nakajima K.
  • Journal Title: J Nucl Cardiol Volume: N/A Issue: 1 Pages: 208-216
  • DOI: 10.1007/s12350-016-0708-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT. (2013)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Masato Yamada, Hiroshi Wakabayashi, Hajima Ichikawa, Hiroyuki Arai, Shinro Matsuo, Junichi Taki, Mitsumasa Hashimoto, Seigo Kinuya.
  • Journal Title: Ann Nucl Med Volume: 28 Issue: 1 Pages: 60-68
  • DOI: 10.1007/s12149-013-0785-6
  • NAID: 120005368235
  • Peer Reviewed / Open Access
• [Presentation] Quantitative evaluation of DNA damage in peripheral blood lymphocytes in patients after cardiac 201Tl/123I-BMIPP study. (2017)
  • Author(s): Koichi Okuda, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Arikawa Tomohiro, Kazumasa Ooiso, Kuniyoshi Iwabuchi, Koji Kajinami, Hisao Tonami.
  • Organizer: EANM 2017
  • Int'l Joint Research
• [Presentation] Evaluation of left ventricular dyssynchrony by phase analysis in gated myocardial perfusion SPECT: Comparison of four software programs. (2017)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Kashiwaya Soichiro, Hiroto Yoneyama, Takayuki Shibutani, Masahisa Onoguchi, Mitsumasa Hashimoto, Seigo Kinuya.
  • Organizer: SNM 2017
  • Int'l Joint Research
• [Presentation] Validation of cross-calibration method for 123I-MIBG heart-to-mediastinum ratio in different combinations of gamma cameras and collimators. (2017)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Kosuke Yamashita, Yumiko Kirihara, Shinro Matsuo, Mitsumasa Hashimoto, Seigo Kinuya.
  • Organizer: ICNC 2017
  • Int'l Joint Research
• [Presentation] XCATファントムとSIMINDモンテカルロシミュレーションを使用したデジタル核医学画像の作成. (2016)
  • Author(s): 奥田光一, 橋本光正，中嶋憲一．
  • Organizer: 第65回 北陸循環器核医学研究会
  • Place of Presentation: ホテル金沢(石川県金沢市)
  • Year and Date: 2016-02-06
• [Presentation] Characteristics of gamma cameras with mediumenergy-type collimators in cardiac 123I-MIBG imaging: A multicenter MIBG phantom study in Japan. (2016)
  • Author(s): K. Okuda, K. Nakajima, C. Kitamura, M. Hori, Y. Kirihara, S. Matsuo, J. Taki, M. Hashimoto, S. Kinuya.
  • Organizer: EANM 2016
  • Place of Presentation: Barcelona (Spain)
  • Int'l Joint Research
• [Presentation] A European phantom study to cross-calibrate myocardial 123I-mIBG scintigraphy. (2016)
  • Author(s): E. Poel, D. O. Verschure, K. Nakajima, K. Okuda, B. L. F. van Eck-Smit, G. A. Somsen, H. J. Verberne.
  • Organizer: EANM 2016
  • Place of Presentation: Barcelona (Spain)
  • Int'l Joint Research
• [Presentation] Multicenter phantom study of characteristics of gamma cameras with LEHR collimators in cardiac 123I-MIBG imaging. (2016)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Masayo Hori, Yumiko Kirihara, Shinro Matsuo, Junichi Taki, Mitsumasa Hashimoto, Seigo Kinuya.
  • Organizer: SNM2016.
  • Place of Presentation: San Diego (USA)
  • Int'l Joint Research
• [Presentation] 500施設のI-123 MIBG専用ファントムデータから得られた心縦隔比の較正値. (2016)
  • Author(s): 奥田光一, 中嶋憲一, 北村千枝美, 堀雅代, 桐原ゆみ子, 松尾信郎, 滝淳一, 橋本光正,絹谷清剛.
  • Organizer: 第36回日本核医学技術学会総会学術大会
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市)
• [Presentation] XCATデジタルファントムによる心臓核医学イメージング. (2016)
  • Author(s): 奥田光一、中嶋憲一、小野口昌久，澁谷孝行，米山寛人，松尾信郎，橋本光正、Paul Segars.
  • Organizer: 第26回 日本心臓核医学会総会・学術大会
  • Place of Presentation: アスト津 (三重県津市)
• [Presentation] 校正ファントム用いたI-123 MIBGの心縦隔比の標準化：散乱線補正(IDW法)における検討 (2015)
  • Author(s): 奥田光一, 中嶋憲一, 青柳弘太, 細谷徹夫, 北村千枝美, 桐原ゆみ子, 松尾信郎, 滝淳一, 橋本光正, 絹谷清剛．
  • Organizer: 第55回 日本核医学会学術総会
  • Place of Presentation: ハイアットリージェンシー東京(東京都新宿区)
  • Year and Date: 2015-11-05
• [Presentation] I-123 MIBG心筋シンチグラフィにおける洗出し率の標準化方法の提案 (2015)
  • Author(s): 奥田光一、中嶋憲一、杉野修一、桐原ゆみ子、橋本光正、絹谷清剛．
  • Organizer: 第51回金沢医科大学医学会学術集会
  • Place of Presentation: 金沢医科大学(石川県河北郡内灘町)
  • Year and Date: 2015-07-18
• [Presentation] Standardization of cardiac I-123 metaiodobenzylguanidine washout rates derived from late 3 and 4 hours imaging. (2015)
  • Author(s): K Okuda, K Nakajima, Y Kirihara, S Sugino, S Matsuo, J Taki, M Hashimoto, S Kinuya.
  • Organizer: ICNC 12, Nuclear Cardiology and Cardiac CT.
  • Place of Presentation: Madrid(Spain)
  • Year and Date: 2015-05-03
  • Int'l Joint Research
• [Presentation] Standardization of cardiac I-123 metaiodobenzylguanidine washout rates derived from late 3 and 4 hours imaging. (2015)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Yumiko Kirihara, Shuichi Sugino, Shinro Matsuo, Junichi Taki, Mitsumasa Hashimoto, Seigo Kinuya.
  • Organizer: ICNC 12 the international Conference on Nuclear Cardiology and Cardiac CT
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-05-03
• [Presentation] Proposal for standardization of cardiac 123I-metaiodobenzylguanidine washout rate. (2014)
  • Author(s): Koichi Okuda, Kenichi Nakajima, Yumiko Kirihara, Shuichi Sugino, Shinro Matsuo, Junichi Taki, Mitsumasa Hashimoto, Seigo Kinuya.
  • Organizer: 11th World Federation of Nuclear Medicine and Biology Congress
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2014-08-27
• [Presentation] I-123 MIBG心筋シンチグラフィーにおける洗出し率の標準化方法の提案. (2014)
  • Author(s): 奥田光一、中嶋憲一、桐原ゆみ子、杉野修一、松尾信郎、滝淳一、橋本光正、絹谷清剛.
  • Organizer: 第24回 日本心臓核医学会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市)
  • Year and Date: 2014-07-19