Synergistic effect carbon-ion irradiation and chemotherapy

• Project/Area Number: 26861026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Jichi Medical University (2016-2017); National Institute of Radiological Sciences (2014-2015)
• Principal Investigator: Wakatsuki Masaru 自治医科大学, 医学部, 教授 (40399449)
• Research Collaborator: SHIBA Shintaro ; IRIE Daisuke
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 炭素イオン線治療 / 重粒子線治療 / 化学放射線治療 / 増感効果 / 炭素イオン線 / 増感作用 / LET / 化学療法 / LET依存性

Outline of Final Research Achievements

To evaluate the synergistic effect of Carbon-ion radiation therapy (C-ion RT) combined with cisplatin for cervical cancer.
We compared the tumor reduction ratio of cervical tumor size between with and without cisplatin in two clinical trials of C-ion RT for cervical cancer. There were significant differences of the reduction ratio between C-ion RT with cisplatin and C-ion RT alone. In vitro experiments, human uterine cervical cancer cells were irradiated with C-ion RT of varied linear energy transfer (LET) with or without exposure of cisplatin. There were significant differences of survival rate comparison with no irradiated cells between with and without exposure of cisplatin in lower LET of C-ion RT. However, there were no significant differences of those in higher LET of C-ion RT.
In conclusion, these result suggested that there were synergistic effects in the lower LET of C-ion RT with cisplatin, but no synergistic effects in higher LET of C-ion RT with cisplatin.

Research Products

• [Journal Article] Carbon-ion radiotherapy for inoperable endometrial carcinoma (2018)
  • Author(s): Irie Daisuke、Okonogi Noriyuki、Wakatsuki Masaru、Kato Shingo、Ohno Tatsuya、Karasawa Kumiko、Kiyohara Hiroki、Kobayashi Daijiro、Tsuji Hiroshi、Nakano Takashi、Kamada Tadashi、Shozu Makio、and The Working Group of the Gynecological Tumor
  • Journal Title: Journal of Radiation Research Volume: - Issue: 3 Pages: 309-315
  • DOI: 10.1093/jrr/rry003
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers (2017)
  • Author(s): Shintaro Shiba, Noriyuki Okonogi, Shingo Kato, Masaru Wakatsuki, Daijiro Kobayashi, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Takashi Nakano, Tadashi Kamada
  • Journal Title: Anticancer Research Volume: 37 Issue: 10 Pages: 5573-5583
  • DOI: 10.21873/anticanres.11991
  • Peer Reviewed
• [Journal Article] Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion (2016)
  • Author(s): Shiba S, Wakatsuki M, Kato S, Ohno T, Okonogi N, Karasawa K, Kiyohara H, Tsujii H, Nakano T, Kamada T, Shozu M; The Working Group of the Gynecological Tumor.
  • Journal Title: Journal of Radiation Research Volume: 57(6) Issue: 6 Pages: 684-690
  • DOI: 10.1093/jrr/rrw070
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy (2016)
  • Author(s): Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Shintaro Shiba, Tadashi Kamada, and Takashi Nakano
  • Journal Title: BMC cancer Volume: 16 Issue: 1 Pages: 244-244
  • DOI: 10.1186/s12885-016-2268-3
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical Trial of Prophylactic Extended-Field Carbon-Ion Radiotherapy for Locally Advanced Uterine Cervical Cancer (Protocol 0508) (2015)
  • Author(s): Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu,
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: e0127587-e0127587
  • DOI: 10.1371/journal.pone.0127587
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Difference in distant failure site between locally advanced squamous cell carcinoma and adenocarcinoma of the uterine cervix after C-ion RT. (2015)
  • Author(s): Masaru Wakatsuki, Shingo Kato, Tatsuya Ohno, Hiroki Kiyohara, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Daisuke Irie, Shintaro Shiba, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu
  • Journal Title: Journal of radiation research Volume: 56 Issue: 3 Pages: 523-528
  • DOI: 10.1093/jrr/rru117
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 悪性腫瘍に対する重粒子線治療 (2017)
  • Author(s): 若月 優
  • Organizer: 第11回埼玉西武放射線医学セミナー
  • Invited
• [Presentation] 子宮頸部腺癌に対する重粒子線治療と化学療法の同時併用の安全性・有効性の検討 (2017)
  • Author(s): 若月 優
  • Organizer: 第59回日本婦人科腫瘍学会学術講演会
  • Invited
• [Presentation] 子宮頸癌放射線治療のこれまでとこれから (2017)
  • Author(s): 若月 優
  • Organizer: 第14回中部放射線治療研究会
  • Invited
• [Presentation] Future globalization of radiation oncology for the younger generation (2016)
  • Author(s): Masaru Wakatsuki
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2016-11-25
  • Int'l Joint Research / Invited
• [Presentation] 子宮頸癌IIB期の新たな戦略－重粒子線治療の可能性－ (2016)
  • Author(s): 若月 優
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] 「定位放射線治療の有用性」 重粒子線治療 (2016)
  • Author(s): 若月 優
  • Organizer: 第19回日本臨床脳神経外科学会
  • Place of Presentation: ホテルガーデンパレス（熊谷）
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] Synergistic action of cisplatin and carbon-ion irradiation in adenocarcinoma of the uterine cervix and HeLa cell line (2015)
  • Author(s): 柴慎太郎、若月 優、他
  • Organizer: 第28回日本放射線腫瘍学会
  • Place of Presentation: 前橋
  • Year and Date: 2015-11-19
• [Presentation] 婦人科癌の粒子線治療とIMRTの可能性 (2015)
  • Author(s): 若月 優
  • Organizer: 第57回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 盛岡
  • Year and Date: 2015-08-07
  • Invited
• [Presentation] Manuscript Title: A clinical trial of prophylactic extended-field carbon-ion radiotherapy for locally advanced uterine cervical cancer (Protocol 0508) (2015)
  • Author(s): 若月 優 他
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] 子宮頸癌IIB期の新たな戦略 重粒子線治療の可能性 (2014)
  • Author(s): 若月 優, 柴 慎太郎, 唐澤 久美子, 鎌田 正
  • Organizer: 第128回関東連合産科婦人科学会総会・学術集会
  • Place of Presentation: 松本
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] 局所進行子宮頸部扁平上皮癌に対する拡大照射野を用いた重粒子線単独治療の有効性と安全性 (2014)
  • Author(s): 若月 優, 加藤 眞吾, 大野 達也, 清原 浩樹, 唐澤 久美子, 安藤 謙, 入江 大介, 柴 慎太郎, 中野 隆史, 鎌田 正, 生水 真紀夫
  • Organizer: 第56回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 宇都宮
  • Year and Date: 2014-07-17