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Development of Novel Radiolabeled Liposomes for Therapy of Solid Tumor

Research Project

Project/Area Number 26861034
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

Hamamichi Shusei  国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 (60721686)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords放射性核種封入リポソーム / 放射性核種 / リポソーム / 固形がん / 内用療法
Outline of Final Research Achievements

Since liposome is well-known to accumulate in the reticuloendothelial system (RES), we focused on characteristics of radioisotope (RI)-ligand complex inside the liposome, and designed new ligands that would reduce accumulation of RI in the non-target organs. Through evaluating multiple RI-encapsulated liposomes by using tumor xenografted mice, we demonstrated that, to achieve clearance of RI from the RES, liposomes needed to be properly degraded in the RES. Based on these results, we proceeded to determine necessary settings for diagnosis and therapy. We synthesized novel ligands and tested their capacities toward minimizing RES accumulation of RI by using aforementioned animal models and methods. In addition, we assessed the application of RI-encapsulated liposome as a biomarker of liposomal anti-cancer agent, and determined that there was a clear correlation between tumor accumulation of RI-encapsulated liposome and pharmacological effectiveness of the liposomal anti-cancer agent.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Radiolabeled Liposome Imaging Determines an Indication for Liposomal Anti-cancer Agent in Ovarian Cancer Mouse Xenograft Models2016

    • Author(s)
      Ito K, Hamamichi S, Asano M, Hori Y, Matsui J, Iwata M, Funahashi Y, Umeda IO, Fujii H
    • Journal Title

      Cancer Science

      Volume: 107(1) Issue: 1 Pages: 60-67

    • DOI

      10.1111/cas.12841

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Tumor Accumulation and Rapid Clearance from the Reticuloendothelial System by 111In-ethylenedicysteine PEGylated Liposome in a Human Head and Neck Cancer Xenograft Model2016

    • Author(s)
      Hamamichi S, Matsuura Y, Ohnuki K, Umeda IO, Fujii H
    • Organizer
      The 11th Annual Meeting of the Japanese Society for Molecular Imaging
    • Place of Presentation
      Kobe
    • Year and Date
      2016-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clearance of radiolabeled liposome from RES in human cancer mouse model2015

    • Author(s)
      Hamamichi S, Matsuura Y, Ohnuki K, Umeda IO, Fujii H
    • Organizer
      The 55th Annual Scientific Meeting of the Japanese Society for Nuclear Medicine
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] SPECT imaging of radiolabeled liposomes predicts effects of liposomal anti-cancer agent in xenograft models2015

    • Author(s)
      Ito K, Hamamichi S, Asano M, Hori Y, Mastui J, Iwata M, Funahashi Y, Umeda IO, Fujii H
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 網内系クリアランスが迅速である放射性核種封入リポソームを用いた診断治療一体化技術の検討2015

    • Author(s)
      濱道修生、松浦祐樹、大貫和信、梅田泉、藤井博史
    • Organizer
      第15回放射性医薬品画像診断薬研究会
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Predictive estimation of therapeutic effect of liposomal anti-cancer agent by SPECT/CT imaging of radioactive liposomes2015

    • Author(s)
      Umeda IO, Ito K, Hamamichi S, Asano M, Iwata M, Mastui J, Hori Y, Funahashi Y, Fujii H
    • Organizer
      World Molecular Imaging Congress 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 111In-ethylenedicysteine Liposomes with High Tumor Accumulation and Rapid Background Clearance in a Human Cancer Xenograft Model2015

    • Author(s)
      Shusei Hamamichi, Yuki Matsuura, Kazunobu Ohnuki, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      第10回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-20 – 2015-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 111In-ethylenedicysteine liposomes with high tumor accumulation and rapid background clearance in a human cancer xenograft model2015

    • Author(s)
      Hamamichi S, Matsuura Y, Ohnuki K, Umeda IO, Fujii H
    • Organizer
      The 10th Annual Meeting of the Japanese Society for Molecular Imaging
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of molecular imaging approach with radionuclide-encapsulated liposomes to evaluate sensitivity of liposomal anti-cancer agent2015

    • Author(s)
      Ito K, Hamamichi S, Asano M, Hori Y, Iwata M, Matsui J, Funahashi Y, Umeda IO, Fujii H
    • Organizer
      The 10th Annual Meeting of the Japanese Society for Molecular Imaging
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cancer theranostics by using radionuclides2015

    • Author(s)
      Fujii H, Umeda IO, Hamamichi S
    • Organizer
      The 10th Annual Meeting of the Japanese Society for Molecular Imaging
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biodistribution patterns of radionuclides through altering chelating ligands in radiolabeled liposomes2014

    • Author(s)
      Shusei Hamamichi, Yuki Matsuura, Kazunobu Ohnuki, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Radiolabeled Liposomes for Theranostic Application toward Cancer Diagnosis and Treatment2014

    • Author(s)
      Shusei Hamamichi, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      第9回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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