| Project/Area Number |
26861035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Miho Ota 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 室長 (00582785)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 磁気共鳴画像 / ポジトロン断層法 / 統合失調症 / メチルフェニデート負荷試験 / ＰＥＴ / ＭＲＩ / ｓｃｈｉｚｏｐｈｒｅｎｉａ |
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| Outline of Final Research Achievements |
The present study was carried out to investigate structural abnormalities associated with autistic spectrum trait in patients with schizophrenia, and functional changes associated with autistic spectrum trait in healthy subjects. We found a significantly negative correlation between autistic spectrum traits and gray matter volume in the left posterior superior temporal region of schizophrenia patients, and positive correlation between the autistic spectrum traits and the regional cerebral blood flow of posterior cingulate cortex in healthy subjects. Additionally, we have examined the use of methylphenidate as a psychostimulant to induce dopamine release and that of [18F]fallypride as a radioligand to quantify the release in a primate model of schizophrenia. We revealed a main effect of the methylphenidate challenge but not the schizophrenia-modeling on the striatal binding potential.
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