Neuroimaging-biomarker for schizophrenia

• Project/Area Number: 26861035
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Miho Ota 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 室長 (00582785)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 磁気共鳴画像 / ポジトロン断層法 / 統合失調症 / メチルフェニデート負荷試験 / ＰＥＴ / ＭＲＩ / ｓｃｈｉｚｏｐｈｒｅｎｉａ

Outline of Final Research Achievements

The present study was carried out to investigate structural abnormalities associated with autistic spectrum trait in patients with schizophrenia, and functional changes associated with autistic spectrum trait in healthy subjects. We found a significantly negative correlation between autistic spectrum traits and gray matter volume in the left posterior superior temporal region of schizophrenia patients, and positive correlation between the autistic spectrum traits and the regional cerebral blood flow of posterior cingulate cortex in healthy subjects. Additionally, we have examined the use of methylphenidate as a psychostimulant to induce dopamine release and that of [18F]fallypride as a radioligand to quantify the release in a primate model of schizophrenia. We revealed a main effect of the methylphenidate challenge but not the schizophrenia-modeling on the striatal binding potential.

Research Products

• [Journal Article] Striatal and extrastriatal dopamine release in the common marmoset brain measured by positron emission tomography and [18F]fallypride. (2015)
  • Author(s): Ota M, Ogawa S, Kato K, Masuda C, Kunugi H.
  • Journal Title: Neurosci Res Volume: １０１ Pages: 1-5
  • DOI: 10.1016/j.neures.2015.07.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Methamphetamine-sensitized rats show augmented dopamine release to methylphenidate stimulation: A positron emission tomography using [18F]fallypride. (2015)
  • Author(s): Ota M, Ogawa S, Kato K, Wakabayashi C, Kunugi H
  • Journal Title: Psychiatry Res Volume: 232 Issue: 1 Pages: 92-97
  • DOI: 10.1016/j.pscychresns.2015.01.023
  • Peer Reviewed
• [Journal Article] Altered coupling of regional cerebral blood flow and brain temperature in schizophrenia compared with bipolar disorder and healthy subjects (2014)
  • Author(s): M Ota, N Sato, K Sakai, M Okazaki, N Maikusa, K Hattori, H Hori, T Teraishi, K Ito, K Yamada, H Kunugi
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: 34 Issue: 12 Pages: 1868-1873
  • DOI: 10.1038/jcbfm.2014.151
  • Peer Reviewed
• [Journal Article] Pseudo-continuous arterial spin labeling MRI study of schizophrenic patients (2014)
  • Author(s): Ota M, Ishikawa M, Sato N, Okazaki M, Maikusa N, Hori H, Hattori K, Teraishi T, Ito K, Kunugi H
  • Journal Title: Schizophrenia Research Volume: 154 Issue: 1-3 Pages: 113-118
  • DOI: 10.1016/j.schres.2014.01.035
  • Peer Reviewed
• [Journal Article] Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: a pseudo-continuous arterial spin labeling (pCASL) study (2014)
  • Author(s): Ota M, Noda T, Sato N, Hattori K, Teraishi T, Hori H, Nagashima A, Shimoji K, Higuchi T, Kunugi H
  • Journal Title: Journal of Affective Disorders Volume: 165 Pages: 59-63
  • DOI: 10.1016/j.jad.2014.04.032
  • Peer Reviewed
• [Presentation] 18F]ファリプリドを用いたコモン・マーモセットの脳内ドパミン放出量の測定 (2015)
  • Author(s): 小川眞太朗, 太田深秀, 加藤孝一, 増田千明, 功刀浩
  • Organizer: 第25回日本臨床精神神経薬理学会
  • Place of Presentation: 東京 京王プラザホテル
  • Year and Date: 2015-10-29
• [Presentation] Neuroimaging などを用いたトランスレーショナルな評価系 (2015)
  • Author(s): 太田深秀
  • Organizer: 第37回日本生物学的精神医学会
  • Place of Presentation: 東京 タワーホール船堀
  • Year and Date: 2015-09-24
  • Invited
• [Presentation] Characteristic distributions of cerebral blood flow changes in major depressive disorder patients (2014)
  • Author(s): 太田深秀 野田隆政 佐藤典子 功刀浩
  • Organizer: 第36回生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01