The role of post-transplant anti-HLA antibodies in chronic rejection.

• Project/Area Number: 26861036
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: Tokodai Kazuaki 東北大学, 大学病院, 助教 (50581641)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抗HLA抗体 / 慢性拒絶 / 小児肝移植 / 慢性拒絶反応 / 肝線維化 / ドナー特異的抗体 / ドナー特異的抗HLA抗体 / 小児生体肝移植 / 肝移植後抗HLA抗体

Outline of Final Research Achievements

We conducted a screening of anti-HLA antibodies for patients who underwent pediatric living donor liver transplantation. In this study, we found that CNI minimization or withdrawal was an independent risk factor for DSA development and that the association between younger age and DSA development was related to reduced CNI dose for recipient growth. Additionally, subgroup analyses for patients with anti-DQ DSAs available showed that low-trough CNI was an independent risk factor for anti-class II DSA development, and that almost all high-MFI DSAs had complement-binding ability.

Research Products

• [Journal Article] Effect of Recipient Age at Liver Transplantation on Prevalence of Post-Transplant Donor-Specific HLA Antibody (2017)
  • Author(s): Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Michiaki Unno, Takashi Kamei
  • Journal Title: ANNALS OF TRANSPLANTATION Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Significance of Screening for HLA Antibodies in the Long-Term Follow-up of Pediatric Liver Transplant Recipients. (2016)
  • Author(s): Tokodai K, Kawagishi N, Miyagi S, Nakanishi C, Hara Y, Fujio A, Kashiwadate T, Maida K, Goto H, Kamei T, Ohuchi N.
  • Journal Title: Transplant Proc. Volume: 48(4) Pages: 1139-41
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Effect of recipient age (<3 years) during liver transplantation on the prevalence of post-transplant class II anti-human leukocyte antigen antibody (2016)
  • Author(s): Kazuaki Tokodai, Naoki Kawagishi, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Takashi Kamei, Noriaki Ohuchi
  • Organizer: 26th INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY
  • Place of Presentation: Hong Kong Convention and Exhibition Centre, 香港
  • Int'l Joint Research
• [Presentation] 小児肝移植後長期経過中における抗HLA抗体スクリーニングの意義に関する検討 (2016)
  • Author(s): 戸子台和哲 川岸直樹 清水健司 吉田悟 宮澤恒持 米田海 原康之 中西史 宮城重人 大内憲明 里見進
  • Organizer: 第52回日本移植学会総会
  • Place of Presentation: グランドプリンスホテル新高輪、品川（東京都）
• [Presentation] Effect of recipient age at liver transplantation on the prevalence of post-transplant donor-specific HLA-DR antibody (2016)
  • Author(s): Kazuaki Tokodai, Naoki Kawagishi, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Takashi Kamei, Noriaki Ohuchi
  • Organizer: Asian Transplantation Week 2016
  • Place of Presentation: 仁川、韓国
  • Int'l Joint Research
• [Presentation] THE SIGNIFICANCE OF SCREENING FOR HUMAN LEUKOCYTE ANTIGEN ANTIBODIES IN THE LONG-TERM FOLLOW-UP OF PEDIATRIC LIVER TRANSPLANT RECIPIENTS (2015)
  • Author(s): Kazuaki Tokodai
  • Organizer: 14th Congress of the Asian Society of Transplantation
  • Place of Presentation: Singapore, Republic of Singapore
  • Year and Date: 2015-08-26
  • Int'l Joint Research