The role of post-transplant anti-HLA antibodies in chronic rejection.
Project/Area Number |
26861036
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 抗HLA抗体 / 慢性拒絶 / 小児肝移植 / 慢性拒絶反応 / 肝線維化 / ドナー特異的抗体 / ドナー特異的抗HLA抗体 / 小児生体肝移植 / 肝移植後抗HLA抗体 |
Outline of Final Research Achievements |
We conducted a screening of anti-HLA antibodies for patients who underwent pediatric living donor liver transplantation. In this study, we found that CNI minimization or withdrawal was an independent risk factor for DSA development and that the association between younger age and DSA development was related to reduced CNI dose for recipient growth. Additionally, subgroup analyses for patients with anti-DQ DSAs available showed that low-trough CNI was an independent risk factor for anti-class II DSA development, and that almost all high-MFI DSAs had complement-binding ability.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] The Significance of Screening for HLA Antibodies in the Long-Term Follow-up of Pediatric Liver Transplant Recipients.2016
Author(s)
Tokodai K, Kawagishi N, Miyagi S, Nakanishi C, Hara Y, Fujio A, Kashiwadate T, Maida K, Goto H, Kamei T, Ohuchi N.
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Journal Title
Transplant Proc.
Volume: 48(4)
Pages: 1139-41
Related Report
Peer Reviewed / Acknowledgement Compliant
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