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Study on optimal immunosuppressive drugs in pancreatic islet transplantation using highly sensitive imaging system

Research Project

Project/Area Number 26861037
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

Nishimura Ryuichi  東北大学, 医学系研究科, 大学院非常勤講師 (90710864)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords膵島移植 / 血管新生 / 免疫抑制剤
Outline of Final Research Achievements

We hypothesized that pancreatic islet revascularization was influenced by not only the use of immunosuppressive drugs, but also by the immunological incompatibility between the donor and recipient, and we evaluated this hypothesis using a highly sensitive imaging system. At 14 days after pancreatic islet transplantation, no significant difference was detected in the newly-formed vascular volume between the pancreatic islet autotransplantation group and the allotransplantation group. These data suggest that the immunological incompatibility between the donor and recipient had only a marginal effect on the revascularization of transplanted islet grafts in pancreatic islet autotransplantation and allotransplantation models.
Furthermore, we attempted to evaluated the impact of immunosuppressive drugs on the poor outcome after pancreatic islet allotransplantation. However, it was difficult to evaluate this by technical problems.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Tacrolimusが移植膵島の血管再構築へ及ぼす影響2014

    • Author(s)
      西村 隆一
    • Journal Title

      移植

      Volume: 49 Pages: 353-362

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Does the immunological incompatibility between the donor and recipient affect pancreatic islet revascularization?2014

    • Author(s)
      西村 隆一
    • Organizer
      World Trasplant Congress 2014
    • Place of Presentation
      Moscone West Convention Center(USA)
    • Year and Date
      2014-07-26 – 2014-07-31
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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