| Project/Area Number |
26861037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 膵島移植 / 血管新生 / 免疫抑制剤 |
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| Outline of Final Research Achievements |
We hypothesized that pancreatic islet revascularization was influenced by not only the use of immunosuppressive drugs, but also by the immunological incompatibility between the donor and recipient, and we evaluated this hypothesis using a highly sensitive imaging system. At 14 days after pancreatic islet transplantation, no significant difference was detected in the newly-formed vascular volume between the pancreatic islet autotransplantation group and the allotransplantation group. These data suggest that the immunological incompatibility between the donor and recipient had only a marginal effect on the revascularization of transplanted islet grafts in pancreatic islet autotransplantation and allotransplantation models.
Furthermore, we attempted to evaluated the impact of immunosuppressive drugs on the poor outcome after pancreatic islet allotransplantation. However, it was difficult to evaluate this by technical problems.
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