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Human 3beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations

Research Project

Project/Area Number 26861041
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionShinshu University

Principal Investigator

HANAMURA Toru  信州大学, 医学部附属病院, 特任研究員 (00532053)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords乳癌 / エストロゲン / アンドロゲン / ステロイド代謝 / 内分泌療法 / 3β-HSD
Outline of Final Research Achievements

The purpose of this study was to investigate the clinical significance of 3β-HSD type 1 in human breast cancer.Using immunohistochemistry (IHC), we evaluated 3β-HSD type 1 expression in 161 human breast cancers.3β-HSD type 1 expression was inversely correlated with invasive tumor size, presence of invasive region, and lymphatic involvement. 3β-HSD type 1 expression was significantly associated with decreased risk of recurrence or improved prognosis by both univariate and multivariate analyses. Our findings indicate that this enzyme is a prognostic factor in hormone-dependent breast cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Human 3β-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations2016

    • Author(s)
      Toru Hanamura
    • Journal Title

      Cancer medicine

      Volume: 印刷中 Issue: 7 Pages: 1405-1415

    • DOI

      10.1002/cam4.708

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 乳癌におけるアンドロゲン代謝酵素、3β-HSD Type1発現の臨床病理学的意義及び予後因子としての意義2015

    • Author(s)
      花村 徹
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2015-07-02 – 2015-07-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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