Human 3beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations
| Project/Area Number |
26861041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
HANAMURA Toru 信州大学, 医学部附属病院, 特任研究員 (00532053)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 乳癌 / エストロゲン / アンドロゲン / ステロイド代謝 / 内分泌療法 / 3β-HSD |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the clinical significance of 3β-HSD type 1 in human breast cancer.Using immunohistochemistry (IHC), we evaluated 3β-HSD type 1 expression in 161 human breast cancers.3β-HSD type 1 expression was inversely correlated with invasive tumor size, presence of invasive region, and lymphatic involvement. 3β-HSD type 1 expression was significantly associated with decreased risk of recurrence or improved prognosis by both univariate and multivariate analyses. Our findings indicate that this enzyme is a prognostic factor in hormone-dependent breast cancer.
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Report
(3 results)
Research Products
(2 results)
