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Elucidation of the interaction between crosstalk between ER and HER2 and drug resistance mechanism in breast cancer

Research Project

Project/Area Number 26861055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionJuntendo University

Principal Investigator

TOKUDA Emi  順天堂大学, 医学部, 非常勤助教 (70621960)

Research Collaborator HORIMOTO yoshiya  順天堂大学, 医学部, 准教授 (40424246)
ARAKAWA Atsushi  順天堂大学, 医学部, 准教授 (70245695)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsER陽性HER2陽性乳癌 / 薬剤耐性 / クロストーク / ハーセプチン耐性 / ERシグナル亢進 / 乳癌 / ER陽性HER陽性 / 薬物療法抵抗性 / ER:HER2 / 薬物治療抵抗性
Outline of Final Research Achievements

We investigated the mechanism of drug resistance on triple-positive breast cancer in which estrogen receptor (ER) and HER2 protein are highly expressed, which are survival and proliferative pathway.
Triple-positive breast cancer cell line: BT474 and BT474-R cells that had established long-term administration of trastuzumab that blocks HER2 signal to BT474 were used to analyze changes of some proteins in signal pathway and change of gene expression. By acquiring resistance to trastuzumab, protein expression of the ER signal was high expressed, and a group of genes producing estrogen were activated.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Open Access: 2 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] ホルモン療法の感受性マーカー2017

    • Author(s)
      徳田恵美 林慎一
    • Journal Title

      がん分子標的治療

      Volume: 15 Pages: 66-71

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] Ki67 expression and the effect of neo-adjuvant chemotherapy on luminal HER2-negative breast cancer.2014

    • Author(s)
      Horimoto Y1, Arakawa A, Tanabe M, Sonoue H, Igari F, Senuma K, Tokuda E, Shimizu H, Kosaka T, Saito M.
    • Journal Title

      BMC cancer

      Volume: 550 Issue: 1

    • DOI

      10.1186/1471-2407-14-550

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ER+HER2+に対する抗HER2療法の最新の知見(実臨床ではあえてこれを選択する)2017

    • Author(s)
      徳田恵美
    • Organizer
      Refinement of the treatment strategy for breast cancer
    • Place of Presentation
      東京 飯田橋
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 汎クラスI PI3K阻害剤とサブユニット特異的阻害剤の各種内分泌療法耐2016

    • Author(s)
      徳田恵美
    • Organizer
      日本乳癌学会 学術総会
    • Place of Presentation
      東京 有明ビックサイト
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳癌の化学療法効果におけるエストロゲンレセプター 蛋白の発現と活性による評価の検討2015

    • Author(s)
      徳田恵美,清水秀穂,堀本義哉,田辺真彦,三浦佳代,齊籐光江,林 慎一,山口ゆり
    • Organizer
      第16回ホルモンと癌研究会
    • Place of Presentation
      岐阜 朝日大学村上記念病院
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 術前化学療法施行症例のKi67の発現変化と術後再発・予後との相関について2015

    • Author(s)
      徳田恵美、島田聡子、猪狩史江、氷室貴規 ほか
    • Organizer
      第23回日本乳癌学会 学術集会
    • Place of Presentation
      東京 東京国際フォーラム
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳癌の化学療法効果予測におけるエストロゲンレセプター発現の意義の検討2014

    • Author(s)
      徳田 恵美 、高橋 由佳 、堀本 義哉 、清水 秀穂 、田辺 真彦 、 中井 克也、齊藤 光江 、清野 祐子、山口 ゆり 、林 慎一
    • Organizer
      第22回日本乳癌学会 学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Triple positive乳癌におけるERとHER2の発現分布についての検討2014

    • Author(s)
      魚森 俊喬、堀本 義哉、齊藤 光江、中井 克也、清水 秀穂、田辺 真彦、徳田 恵美、毛利かの子、荒川 敦
    • Organizer
      第22回日本乳癌学会 学術総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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