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The development of treatments for suppression of liver fibrosis in the NASH by S1P, adenosine and thrombopoietin

Research Project

Project/Area Number 26861059
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

Hisakura Katsuji  筑波大学, 医学医療系, 講師 (60550168)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsNASH / 肝臓X受容体 / インスリン抵抗性 / NAFLD
Outline of Final Research Achievements

Recently,non-alcoholic steatohepatitis has been increasingly, however, the pathogenesis remains largely unknown and there is almost no effective treatment. This is contribute to absent of suitable model. We tried to create of novel animal model of NASH for development of basic study of NASH. We established a novel mouse model which reflect hepatic histopathology of human NASH by administration of Liver X receptor activator and carbon tetrachloride. We think that this model is more superior than existing fasting model which used widely for basic study of NASH because this model has insulin resistance.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results)

  • [Presentation] 肝臓X受容体に着目した新規NASHモデル動物の開発2016

    • Author(s)
      大和田洋平,田村孝史,田野井智倫,久倉勝治,松坂 賢,島野 仁,大河内信弘
    • Organizer
      第102回 日本消化器病学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-04-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓X受容体に着目した新規NASHモデル動物の開発2015

    • Author(s)
      田村孝史,大和田洋平,田野井智倫,久倉勝治,大河内信弘
    • Organizer
      第22回肝細胞研究会
    • Place of Presentation
      米子コンベンションセンター(鳥取県米子市)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓X受容体作動薬および四塩化炭素併用投与による新規NASHモデル動物の開発2015

    • Author(s)
      田野井智倫,田村孝史,大和田洋平,久倉勝治,高野恵輔,福永 潔,大河内信弘
    • Organizer
      第51回 日本肝臓学会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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