The development of treatments for suppression of liver fibrosis in the NASH by S1P, adenosine and thrombopoietin
| Project/Area Number |
26861059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NASH / 肝臓X受容体 / インスリン抵抗性 / NAFLD |
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| Outline of Final Research Achievements |
Recently,non-alcoholic steatohepatitis has been increasingly, however, the pathogenesis remains largely unknown and there is almost no effective treatment. This is contribute to absent of suitable model. We tried to create of novel animal model of NASH for development of basic study of NASH. We established a novel mouse model which reflect hepatic histopathology of human NASH by administration of Liver X receptor activator and carbon tetrachloride. We think that this model is more superior than existing fasting model which used widely for basic study of NASH because this model has insulin resistance.
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Report
(3 results)
Research Products
(3 results)
