The development of treatments for suppression of liver fibrosis in the NASH by S1P, adenosine and thrombopoietin

Research Project

Project/Area Number	26861059
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	University of Tsukuba
Principal Investigator	Hisakura Katsuji 筑波大学, 医学医療系, 講師 (60550168)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	NASH / 肝臓X受容体 / インスリン抵抗性 / NAFLD
Outline of Final Research Achievements	Recently,non-alcoholic steatohepatitis has been increasingly, however, the pathogenesis remains largely unknown and there is almost no effective treatment. This is contribute to absent of suitable model. We tried to create of novel animal model of NASH for development of basic study of NASH. We established a novel mouse model which reflect hepatic histopathology of human NASH by administration of Liver X receptor activator and carbon tetrachloride. We think that this model is more superior than existing fasting model which used widely for basic study of NASH because this model has insulin resistance.

Report

(3 results)