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Prediction of response to chemotherapy of colorectal liver metastases based on the tumor genetic profile

Research Project

Project/Area Number 26861063
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionOkinaka Memorial Institute for Medical Research

Principal Investigator

Shindoh Junichi  公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (90701037)

Co-Investigator(Renkei-kenkyūsha) Kokudo Norihiro  東京大学, 医学部・肝胆膵外科, 教授 (00205361)
Research Collaborator Nishioka Yujiro  東京大学, 医学部肝胆膵外科
Yoshioka Ryuji  東京大学, 医学部肝胆膵外科
Gonoi Wataru  東京大学, 医学部放射線科
Abe Hiroyuki  東京大学, 医学部病理部
Okura Naoki  東京大学, 医学部放射線科
Yoshida Shuntaro  東京大学, 医学部消化器内科
Mitsui Jun  東京大学, 医学部神経内科
Hasegawa Kihoshi  東京大学, 医学部肝胆膵外科
Fukayama Masashi  東京大学, 医学部病理部
Tsuji Shoji  東京大学, 医学部神経内科
Hashimoto Masaji  虎の門病院, 消化器外科
Watanabe Goro  虎の門病院, 消化器外科
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords大腸癌 / 肝転移 / 化学療法 / 遺伝子変異
Outline of Final Research Achievements

Genome-wide analysis for pilot samples from 10 patients with colorectal liver metastases (CLM) revealed that polymorphism in transmembrane region of MICA gene could be a new biomarker for response to chemotherapy and postoperative prognosis. Validation analysis using samples from 58 patients confirmed very high concordance rate in MICA genotype between tumor tissue and normal liver parenchyma (96.4%) and that MICA A5.1 is associated with pathologic response to chemotherapy and better survival outcomes. These results suggest that MICA genotype can be a potential biomarker for patients undergoing chemotherapy and surgery for CLM.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Kinetic changes in liver parenchyma after preoperative chemotherapy for patients with colorectal liver metastases2017

    • Author(s)
      Tani K, Shindoh J, Takamoto T, Nishioka Y, Hashimoto T, Sakamoto Y, Hasegawa K, Makuuchi M, Kokudo N
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 印刷中 Issue: 5 Pages: 813-821

    • DOI

      10.1007/s11605-017-3359-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] KRAS Mutation Status Predicts Site-Specific Recurrence and Survival After Resection of Colorectal Liver Metastases Irrespective of Location of the Primary Lesion2016

    • Author(s)
      Shindoh J, Nishioka Y, Yoshioka R, Sugawara T, Sakamoto Y, Hasegawa K, Hashimoto M, Kokudo N
    • Journal Title

      Annals of Surgical Oncology

      Volume: 未定

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Radiological Morphology of Colorectal Liver Metastases after Preoperative Chemotherapy Predicts Tumor Viability and Postoperative Outcomes.2015

    • Author(s)
      Nishioka Y, Shindoh J, Yoshioka R, Gonoi W, Abe H, Okura N, Yoshida S, Oba M, Hashimoto M, Watanabe G, Hasegawa K, Kokudo N.
    • Journal Title

      J Gastrointest Surg.

      Volume: 19 Issue: 9 Pages: 1653-1661

    • DOI

      10.1007/s11605-015-2836-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiological Morphology of Colorectal Liver Metastases after Preoperative Chemotherapy Predicts Tumor Viability and Postoperative Outcomes2015

    • Author(s)
      Nishioka Y, Shindoh J, Yoshioka R, Wataru G, Abe H, Okura N, Yoshida S, Oba M, Hashimoto M, Watanabe g, Hasegawa K, Kokudo N
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Multidisciplinary treatment of colorectal liver metastases2017

    • Author(s)
      Junichi Shindoh
    • Organizer
      8th bi-anual meeting of the Brazilian Chapter of the International Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Porto Alegre
    • Year and Date
      2017-09-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大腸癌肝転移治療におけるmultidisciplinary approachの重要性:肝臓外科医の立場から2017

    • Author(s)
      進藤潤一
    • Organizer
      第72回日本消化器外科学会総会
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2017-07-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 腫瘍学的時間軸を考慮した大腸癌肝転移に対する切除の根治性予測と切除適応の判断に関する検討2017

    • Author(s)
      進藤潤一
    • Organizer
      第103回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2017-04-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Significance of multidisciplinary approach for advanced colorectal liver metastases2017

    • Author(s)
      Junichi Shindoh
    • Organizer
      2nd Eastern and Western Association Liver Tumors
    • Place of Presentation
      星陵会館
    • Year and Date
      2017-01-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical impact and optimal use of perioperative chemotherapy for synchronous colorectal liver metastases2016

    • Author(s)
      進藤潤一
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Response to chemotherapy and surgical outcomes of colorectal liver metastases based on KRAS mutation status2016

    • Author(s)
      進藤潤一
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Significance of multidisiplinary approach and actual conversion rate for advanced colorectal liver metastases2016

    • Author(s)
      進藤潤一
    • Organizer
      第28回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 術前化学療法へのレスポンスからみたStage IV大腸癌の切除効果予測2015

    • Author(s)
      進藤潤一
    • Organizer
      第77回日本臨床外科学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 化学療法に対するCT画像上の形態学的変化2015

    • Author(s)
      進藤潤一
    • Organizer
      第51回日本肝癌研究会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] サイズと形で切る!大腸癌多発肝転移2015

    • Author(s)
      進藤潤一
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Stage IVでも諦めない大腸癌肝転移に対する集学的治療2015

    • Author(s)
      進藤潤一
    • Organizer
      第27回日本肝胆膵外科学会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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