Relationship between portal venous congestion and functions of splanchnic organs

Research Project

Project/Area Number	26861064
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Kanazawa University
Principal Investigator	Hayashi Hironori 金沢大学, 大学病院, 助教 (20543656)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	小腸 / 門脈 / 肝臓 / うっ血 / アポトーシス / プレコンディショニング
Outline of Final Research Achievements	In clinical settings of hepato-pancreato-biliary and liver transplant surgery, portal venous congestion (PVC) is common pathophysiology. Therefore, effect and therapeutic approach for PVC was investigated by rat model. Intestinal mucosa was injured by PVC via apoptosis. By the induction of congestive preconditioning (CPC), intestinal mucosal injury and survival rate were significantly improved. The anti-apoptotic pathways was suspected to be involved in this availability, based on the result from immunohistochemical analysis.

Report

(3 results)