Influence of prevention of ischemic reperfusion and liver regeneration by rejuvunated liver through gene insertion
Project/Area Number |
26861087
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Nagasaki University |
Principal Investigator |
HIDAKA Masaaki 長崎大学, 病院(医学系), 助教 (10457541)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 老化 / 肝再生 / 生体肝移植 / 高齢ドナー / 肝グラフト / 移植 / 虚血再灌流 |
Outline of Final Research Achievements |
We investigated that anti-aging gene affected the outcome about the model of ischemic reperfusion on elderly mice because the outcome from elderly donor in living donor liver transplantation (LDLT) was worse than the younger donor. We investigated the expression of macrophage in the donor liver in LDLT and influence of liver macrophage to the outcome after LDLT. There were a few macrophages in elderly donor than in younger donor on the liver biopsy. The infectious complications after LDLT was independently happened in less macrophage group in elderly donor. Multivariate analysis showed that the less macrophage was independent factor of graft loss of LDLT in elderly donor. We investigated the comparison of the expression of anti-aging gene between younger and elderly mice. Also we investigated the expression of anti-aging gene, inflammation cytokine in the ischemic reperfusion model in the rodent. The anti-aging gene was not more expressed in the elderly mice by anti-aging agent.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Aspartate transaminase-platelet ratio and Fibrosis-4 indices as effective markers for monitoring esophageal varices in HIV/hepatitis C virus co-infected patients due to contaminated blood products for hemophilia.2017
Author(s)
Natsuda K, Takatsuki M, Tanaka T, Soyama A, Adachi T, Ono S, Hara T, Baimakhanov Z, Imamura H, Okada S, Hidaka M, Eguchi S.
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Journal Title
Hepatology Research
Volume: 印刷中
Issue: 12
Pages: 1282-1288
DOI
Related Report
Peer Reviewed
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[Journal Article] he kupffer cell number affects the outcome of living donor liver transplantation from elderly donors.2016
Author(s)
Hidaka M, Eguchi S, Takatsuki M, Soyama A, Ono S, Adachi T, Natsuda K, Kugiyama T, Hara T, Okada S, Imamura H, Miuma S, Miyaaki H.
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Journal Title
Transplantation Direct
Volume: 2
Issue: 8
Pages: e94-e94
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Analysis of early relaparotpmy following living donor liver transplantation.2016
Author(s)
Hara T, Soyama A, Hidaka M, Kitasato A, Ono S, Natsuda K, Kugiyama T, Imamura H, Okada S, Baimakhanov Z, Kuroki T, Eguchi S.
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Journal Title
Liver transplantation
Volume: 22
Issue: 11
Pages: 1519-1525
DOI
Related Report
Peer Reviewed
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[Journal Article] Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver2016
Author(s)
Shuai Zhang, Tao-Sheng Li, Akihiko Soyama, Takayuki Tanaka, Chen Yan, Yusuke Sakai, Masaaki Hidaka, Ayaka Kinoshita, Koji Natsuda, Mio Fujii, Tota Kugiyama, Zhassulan Baimakhanov, Tamotsu Kuroki, Weili Gu, Susumu Eguchi
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 26540-26540
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan2016
Author(s)
Eguchi S, Takatsuki M, Soyama A, Hidaka M, Kugiyama T, Natsuda K, Adachi T, Kitasato A, Fujita F, Kuroki T.
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 69
Issue: 1
Pages: 80-82
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed
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[Journal Article] Does the development of chronic kidney disease and acute kidney injury affect the prognosis after living donor liver transplantation?2016
Author(s)
Inoue Y, Soyama A, Takatsuki M, Hidaka M, Kinoshita A, Natsuda K, Baimakhanov Z, Kugiyama T, Adachi T, Kitasato A, Kuroki T, Eguchi S.
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Journal Title
Clin Transplant.
Volume: 30
Issue: 5
Pages: 518-27
DOI
Related Report
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[Journal Article] E-cadherin expression in hepatocellular carcinoma treated with previous local treatment in patients undergoing living donor liver transplantation.2015
Author(s)
Kugiyama T, Hidaka M, Soyama A, Takatsuki M, Natsuda K, Kinoshita A, Carpenter I, Adachi T, Kitasato A, Kuroki T, Eguchi S.
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Journal Title
Transplant Proc.
Volume: 47
Issue: 3
Pages: 700-2
DOI
Related Report
Peer Reviewed
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[Journal Article] A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan.2015
Author(s)
Inagaki Y, Oshiro Y, Tanaka T, Yoshizumi T, Okajima H, Ishiyama K, Nakanishi C, Hidaka M, Wada H, Hibi T, Takagi K, Honda M, Kuramitsu K, Tanaka H, Tohyama T, Ikegami T, Imura S, Shimamura T, Nakayama Y, Urahashi T, Yamagishi K, Ohnishi H, Nagashima S, Takahashi M, Shirabe K, Kokudo N, Okamoto H, Ohkohchi N.
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Journal Title
EBioMedicine.
Volume: 24
Pages: 1607-1612
NAID
Related Report
Peer Reviewed
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[Journal Article] A Method for Performing Islet Transplantation Using Tissue-Engineered Sheets of Islets and Mesenchymal Stem Cells.2015
Author(s)
Hirabaru M, Kuroki T, Adachi T, Kitasato A, Ono S, Tanaka T, Matsushima H, Sakai Y, Soyama A, Hidaka M, Yamanouchi K, Takatsuki M, Okano T, Eguchi S.
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Journal Title
Tissue Eng Part C Methods.
Volume: 21
Issue: 12
Pages: 1205-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Vascularized subcutaneous human liver tissue from engineered hepatocyte/fibroblast sheets in mice2015
Author(s)
Yusuke Sakai, Kosho Yamanouchi, Kazuo Ohashi, Makiko Koike, Rie Utoh, Hideko Hasegawa, Izumi Muraoka, Takashi Suematsu, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
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Journal Title
Biomaterials
Volume: 65
Pages: 66-75
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Efficacy of multi-layered hepatocyte sheet transplantation for radiation-induced liver damage and partial hepatectomy in a rat model2015
Author(s)
Zhassulan Baimakhanov, Kosho Yamanouchi, Yusuke Sakai, Makiko Koike, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Fumihiko Fujita, Kengo Kanetaka, Tamotsu Kuroki, Susumu Eguchi
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Journal Title
Cell Transplantation
Volume: 25
Issue: 3
Pages: 549-558
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma.2015
Author(s)
Matsushima H, Kuroki T, Kitasato A, Adachi T, Tanaka T, Hirabaru M, Hirayama T, Kuroshima N, Hidaka M, Soyama A, Takatsuki M, Kinoshita N, Sano K, Nishida N, Eguchi S.
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Journal Title
Dig Liver Dis.
Volume: 47
Issue: 12
Pages: 1067-75
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD4 T lymphocyte counts in patients undergoing splenectomy during living donor liver transplantation.2015
Author(s)
Natsuda K, Eguchi S, Takatsuki M, Soyama A, Hidaka M, Hara T, Kugiyama T, Baimakhanov Z, Ono S, Kitasato A, Fujita F, Kanetaka K, Kuroki T.
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Journal Title
Transpl Immunol.
Volume: 34
Pages: 50-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of the hepatic functional reserve, portal hypertension, and prognosis of patients with human immunodeficiency virus/hepatitis C virus coinfection through contaminated blood products in Japan.2014
Author(s)
Eguchi S, Takatsuki M, Soyama A, Hidaka M, Nakao K, Shirasaka T, Yamamoto M, Tachikawa N, Gatanaga H, Kugiyama Y, Yatsuhashi H, Ichida T, Kokudo N.
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Journal Title
Transplant Proc.
Volume: 46
Pages: 736-738
NAID
Related Report
Peer Reviewed
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[Presentation] Outcomes of LT, Hepatic resection, Local therapy for HCC less than 3 cm and 3 nodules2016
Author(s)
Masaaki Hidaka, Akihiko Soyama, Tomohiko Adachi, Shinichiro Ono, Koji Natsuda, Takanobu Hara, Fumihiko Fujita, Kengo Kanetaka, Mitsuhisa Takatsuki, Susumu Eguchi
Organizer
World Congress of International college of surgeons
Place of Presentation
京都市、京都府 京都国際会館
Year and Date
2016-11-23
Related Report
Int'l Joint Research
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