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New treatment strategy via autophagy for pancreatic adenocarcinoma.

Research Project

Project/Area Number 26861089
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

HASHIMOTO Daisuke  熊本大学, 医学部附属病院, 助教 (80508507)

Research Collaborator SAKATA Kazuya  熊本大学, 医学部附属病院, 非常勤診療医師
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオートファジー / 膵癌 / ゲムシタビン / フルオロウラシル / 5-FU
Outline of Final Research Achievements

Autophagy is a regulated process of degradation and recycling of cellular constituents. The role of autophagy in pancreatic cancer is still not clear. The aim of this study was to investigate the role of autophagy in pancreatic cancer, and to provide insights into new strategies for treatment.
During study period, about 50 patients with pancreatic cancer underwent pancreatic resection. Autophagy was significantly induced in pancreatic ductal adenocarcinoma compared to healthy pancreatic tissue in these patients. The association of autophagy status with long-term survival has been analyzed.
In pancreatic cancer cell lines, autophagy contributes to pancreatic cancer cell growth, and has a cytoprotective effect against anti-cancer drug. These data were published in Euro J Cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Residual total pancreatectomy: short- and long-term outcome Pancreatol.2016

    • Author(s)
      Hashimoto D, Chikamoto A, Sakata K, Taki K, Inoue R, Arima K, Hayashi H, Ohmuraya M, Hirota M, Baba H
    • Journal Title

      Pancreatol

      Volume: in press Issue: 4 Pages: 646-51

    • DOI

      10.1016/j.pan.2016.04.034

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unused sterile instruments for closure prevents wound SSI after pancreatic surgery.2016

    • Author(s)
      Hashimoto D, Chikamoto A, Arima K, Taki T, Inoue R, Imai K, Yamashita Y, Baba H.
    • Journal Title

      J Surg Res

      Volume: in press Issue: 1 Pages: 38-42

    • DOI

      10.1016/j.jss.2016.02.044

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of KRAS mutations in pancreatic ductal adenocarcinoma.2016

    • Author(s)
      Hashimoto D, Arima K, Yokoyama N, Chikamoto A, Taki T, Inoue R, Kaida T, Higashi T, Nitta H, Ohmuraya M, Hirota M, Beppu T, Baba H.
    • Journal Title

      Pancreas

      Volume: Epub ahead of print

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KRAS, BRAF, PIK3CA Mutations and Patient Prognosis in 126 Pancreatic Cancers: Pyrosequencing Technology and Literature Review.2016

    • Author(s)
      Zhou L, Baba Y, Kitano Y, Miyake K, Zhang X, Yamamura K, Kosumi K, Kaida T, Arima K, Taki K, Higashi T, Imai K, Hashimoto D, Yamashita Y, Chikamoto A, Beppu T, Tan X, Baba H.
    • Journal Title

      Med Oncol

      Volume: 33(4) Issue: 4 Pages: 32-32

    • DOI

      10.1007/s12032-016-0745-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases.2016

    • Author(s)
      Arima K, Okabe H, Hashimoto D, Chikamoto A, Tsuji A, Yamamura K, Kitano Y, Inoue R, Kaida T, Higashi T, Taki K, Imai K, Beppu T, Baba H.
    • Journal Title

      Int J Clin Oncol

      Volume: Epub ahead of print

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells.2015

    • Author(s)
      Higashi, T., Hayashi, H., Ishimoto, T., Takeyama, H., Kaida, T., Arima, K., Taki, K., Sakamoto, K., Kuroki, H., Okabe, H., Nitta, H., Hashimoto, D., Chikamoto, A., Beppu, T., Baba, H.
    • Journal Title

      Br J Cancer

      Volume: 14;113(2) Issue: 2 Pages: 252-8

    • DOI

      10.1038/bjc.2015.170

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant soluble thrombomodulin for postoperative disseminated intravascular coagulation.2015

    • Author(s)
      Hashimoto D, Chikamoto A, Miyanari N, Ohara C, Kuramoto M, Horino K, Ohshima H, Baba H.
    • Journal Title

      J Surg Res

      Volume: 197(2) Issue: 2 Pages: 405-11

    • DOI

      10.1016/j.jss.2015.04.048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers.2015

    • Author(s)
      Hashimoto, D., Chikamoto, A., Sakata, K., Nakagawa, S., Hayashi, H., Ohmuraya, M., Hirota, M., Yoshida, N., Beppu, T. and Baba, H.
    • Journal Title

      Asian journal of endoscopic surgery.

      Volume: 8 Issue: 1 Pages: 59-62

    • DOI

      10.1111/ases.12138

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accessory right hepatic artery branched from gastroduodenal artery.2015

    • Author(s)
      Yamashita K, Hashimoto D, Itoyama R, Okabe H, Chikamoto A, Beppu T, Baba H.
    • Journal Title

      Surg Case Rep

      Volume: 1 Issue: 1 Pages: 90-90

    • DOI

      10.1186/s40792-015-0092-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful surgical internal drainage of postoperative pancreatic pseudocyst through pancreaticojejunostomy with distal pancreatectomy: a case report2015

    • Author(s)
      Sakata K, Hashimoto D, Taki K, Nakahara O, Ohmuraya M, Chikamoto A, Beppu T, Baba H
    • Journal Title

      Surg Case Rep

      Volume: 1 Issue: 1 Pages: 54-54

    • DOI

      10.1186/s40792-015-0057-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatobiliary and Pancreatic: Skin metastases from cholangiocarcinoma mimicking herpes zoster.2015

    • Author(s)
      Okabe H, Hashimoto D, Chikamoto A, Hayashi H, Nitta H, Taki K, Higashi T, Arima K, Ishiko T, Beppu T, Baba H
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 30(9) Issue: 9 Pages: 1337-1337

    • DOI

      10.1111/jgh.12964

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive lymphoid hyperplasia of the liver requires differential diagnosis of hepatocellular carcinoma.2015

    • Author(s)
      Higashi T, Hashimoto D, Beppu T, Kaida T, Arima K, Takeyama H, Taki K, Sakamoto K, Sakata K, Hayashi H, Nitta H, Chikamoto A, Honda Y, Inomata Y, Baba H.
    • Journal Title

      Surg Case Rep

      Volume: 1 Issue: 1 Pages: 31-31

    • DOI

      10.1186/s40792-015-0034-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute gastric volvulus in a patient with trisomy 21.2015

    • Author(s)
      Arima K, Hashimoto D, Takata N, Doi Y, Yoshinaka I, Harada K, Baba H.
    • Journal Title

      Surg Case Rep

      Volume: 1 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s40792-014-0005-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy.2015

    • Author(s)
      Eri Oda, Daisuke Hashimoto, Yuko Shiomi, Koji Ohnishi, Hiromitsu Hayashi, Akira Chikamoto, Motohiro Takeya, Hideo Baba
    • Journal Title

      Surgical case reports

      Volume: 1 Issue: 1 Pages: 101-101

    • DOI

      10.1186/s40792-015-0106-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pancreas-preserving partial duodenectomy of the distal regionpart for large duodenal adenoma: Rreport of a case.2015

    • Author(s)
      Shimizu K, Hashimoto D, Abe S, Chikamoto A, Baba H.
    • Journal Title

      Surg Today

      Volume: 45(3) Issue: 3 Pages: 390-393

    • DOI

      10.1007/s00595-014-0868-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of postoperative weight loss on survival after resection for pancreatic cancer.2014

    • Author(s)
      Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.
    • Journal Title

      J Parenter Enteral Nutr.

      Volume: Epub ahead of print Issue: 5 Pages: 598-603

    • DOI

      10.1177/0148607114520992

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs2014

    • Author(s)
      Hashimoto D, Bläuer M, Hirota M, Ikonen NH, Sand J, Laukkarinen J
    • Journal Title

      Eur J Cancer

      Volume: 50(7) Issue: 7 Pages: 1382-90

    • DOI

      10.1016/j.ejca.2014.01.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy.2013

    • Author(s)
      Hashimoto D, Chikamoto A, Ohmuraya M, Hirota M, Baba H
    • Journal Title

      Surg Today

      Volume: - Issue: 7 Pages: 1207-1213

    • DOI

      10.1007/s00595-013-0662-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic cancer in the remnant pancreas following primary pancreatic resection.2013

    • Author(s)
      Hashimoto D, Chikamoto A, Ohmuraya M, Sakata K, Miyake K, Kuroki H, Watanabe M, Beppu T, Hirota M, Baba H.
    • Journal Title

      Surg Today

      Volume: - Issue: 7 Pages: 1313-1320

    • DOI

      10.1007/s00595-013-0708-0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 高齢者に対して膵頭十二指腸切除術を安全に行うために2015

    • Author(s)
      橋本大輔、近本 亮、辻 顕、山村謙介、井上梨沙、有馬浩太、髙城克暢、東孝暁、新田英利、別府透、馬場秀夫
    • Organizer
      第77回日本臨床外科学会総会
    • Place of Presentation
      福岡サンパレス
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Heterogeneity of KRAS mutation in pancreatic ductal adenocarcinoma.2015

    • Author(s)
      Daisuke Hashimoto、Kota Arima,Akira Chikamoto,Katsunobu Taki,Risa Inoue,Takayoshi Kaida,Takaaki Higashi,Hidetoshi Nitta,Hiromitsu Hayashi,Hideo Baba
    • Organizer
      The 47th European Pancreatic Club
    • Place of Presentation
      Palacio de Congresos de Toledo El Greco
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵液瘻はゼロにできるのか?膵空腸挿入吻合法と膵管空腸吻合法2015

    • Author(s)
      橋本大輔、有馬浩太、井上梨沙、髙城克暢、甲斐田剛圭、東孝暁、武山秀晶、新田英利、林洋光、岡部弘尚、近本亮、別府透、馬場秀夫
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      ホテルグランパシフィック LE DAIBA(東京都)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膵頭十二指腸切除術後の合併症死亡ゼロを目指して2015

    • Author(s)
      橋本大輔、近本亮、坂田和也、岡部弘尚、髙城克暢、井上梨沙、有馬浩太、新田英利、林洋光、別府透、馬場秀夫
    • Organizer
      第115回 日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] オートファジー機能不全がもたらす慢性膵炎の発症機構2014

    • Author(s)
      坂田 和也
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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