Development of diagnostic method of fluorescence during colorectal cancer surgery using 5-aminolevulinic acid and ICG

• Project/Area Number: 26861090
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: BABA KENJI 鹿児島大学, 附属病院, 医員 (30642615)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 大腸癌 / 腹腔鏡手術 / 蛍光診断法 / 光力学診断 / 光力学的診断

Outline of Final Research Achievements

Recently, laparoscopic surgery for colorectal cancer has been spreading as a standard surgical procedure in addition to laparotomy surgery. The purpose of this study is development of method to identify colorectal cancer mainly using fluorescent endoscopy under laparoscopic surgery. We used commonly available ICG for colorectal cancer surgery, and examined how ICG can be detected in the patient intraperitoneal under the fluorescence laparoscopey . We confirmed that it is possible to evaluate intestinal blood flow after intravenous administration, and it is possible to identify lymph flow and lymph nodes around the tumor by direct injection in the vicinity of the tumor. We reported that laparoscopic colorectal surgery using these methods was safe and new technique in several academic societies.

Research Products

• [Journal Article] Laparoscopic complete mesocolic excision via combined medial and cranial approaches for transverse colon cancer. (2017)
  • Author(s): Mori S, Kita Y, Baba K
  • Journal Title: Surg Today Volume: 47 Pages: 643-946
  • Peer Reviewed
• [Journal Article] 減孔式手術を行った小腸粘膜下動脈瘤破裂の1例 (2016)
  • Author(s): 下之薗将貴 盛 真一郎 馬場 研二
  • Journal Title: 外科 Volume: 73 Pages: 1228-1232
  • Peer Reviewed
• [Presentation] Intracorporeal anastomosis in laparoscopic colectomy for StageI colon cancer (2017)
  • Author(s): Kenji Baba, Shinichiro Mori,Yoshiaki Kita, Masayuki Yanagi, Kan Tanabe,Tesuya Ijichi, Yasuto Uchikado, Hiroshi Kurahara, Yoshikazu Uenosono, Yuko Mataki, Masahiko Sakoda, Akihiro Nakajo, Kosei Maemura, Shoji Natsugoe
  • Organizer: SAGES
  • Place of Presentation: Houston(アメリカ）
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] StageI結腸癌に対する腹腔鏡下結腸切除術における体内吻合 (2016)
  • Author(s): 馬場研二 盛真一郎 喜多芳昭
  • Organizer: 第29回日本内視鏡外科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-08
• [Presentation] 右側結腸癌に対するmesofascial separationによる腹腔鏡下手術 (2016)
  • Author(s): 盛真一郎 喜多芳昭 馬場研二
  • Organizer: 第78回日本臨床外科学会総会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2016-11-24
• [Presentation] 腹腔鏡下左半結腸切除術における体内吻合の２例 (2016)
  • Author(s): 馬場研二 盛真一郎 喜多芳昭
  • Organizer: 第70回手術手技研究会
  • Place of Presentation: 東京コンファレンスセンター品川（東京都港区）
  • Year and Date: 2016-05-21
• [Presentation] 腹腔鏡下左半結腸切除術における体内吻合の２例 (2016)
  • Author(s): 馬場研二
  • Organizer: 第７０回手術手技研究会
  • Place of Presentation: 東京コンファレンスセンター・品川
  • Year and Date: 2016-05-21