| Project/Area Number |
26861096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SHIMIZU Atsushi 和歌山県立医科大学, 医学部, その他 (00637910)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MUC16 / mesothelin / IPMN / ペプチドワクチン療法 / 膵管内乳頭粘液性腫瘍 |
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| Outline of Final Research Achievements |
MUC16 and mesothelin has been hopeful as a newly target gene for pancreatic ductal adenocarcinoma. In this studty, we investigated the clinicopathological and molecular biological function of MUC16 and mesothelin for the intraductal papillary mucinous neoplasm (IPMN) to develop the cancer peptide vaccine therapy. In the result, MUC16/mesothelin were not expressed in the low-, intermediate, and high- grade dysplasia, but expressed invasive IPMC. However, MUC16/mesothelin high expression was not an independent prognostic factor for overall survival. We cultured the cell line of IPMC derived from surgical specimens and performed the expression and co-expression analyses of MUC16/mesothelin.
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