| Project/Area Number |
26861099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
Hayata keiji 和歌山県立医科大学, 医学部, 学内助教 (90637654)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | IL-17 / 腫瘍免疫 / 血管新生 / がん幹細胞 / 腹膜転移 / 消化器癌 / 腫瘍免疫逃避機構 |
|---|
| Outline of Final Research Achievements |
The inhibiting IL-17 in the peritoneal metastasis model of gastrointestinal cancer in mice releases the tumor immunity escape mechanism of Treg cells and MDSC, produces a Th1 dominant immune environment, and augments anti-tumor immunity. Furthermore, the inhibition of IL-17 suppressed angiogenesis, however, it could not reduce cancer stem cells. IL-17 is one of new molecular targets in peritoneal metastasis of gastrointestinal cancer.
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