A novel split liver protocol using the subnormothermic oxygenated circuit system in a marginal donor procedure
Project/Area Number |
26861101
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
|
Research Institution | Jichi Medical University |
Principal Investigator |
Okada Noriki 自治医科大学, 医学部, 臨床助教 (40611786)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 常温酸素化灌流 / 肝移植 / 臓器保存 / 分割肝移植 / 脳死肝移植 / 臓器灌流装置 / ブタ実験モデル |
Outline of Final Research Achievements |
This study was performed with the goal of devising a new split liver protocol. First, as the research of appropriate condition of subnormothermic oxygenated prefusion, the necessity of the oxygen carrier was examined. It is suggested that the oxygen carrier makes higher graft preservative effect. Second, a novel split liver protocol using the subnormotheric oxygenated circuit system in a porcine model was performed.This study revealed that the subnormothermic oxygenated circuit system is more efective than cold storage which has been used in clinical situation in split liver protocol. This protocol may help to overcome the lack of brain-death donor liver graft.
|
Report
(3 results)
Research Products
(2 results)
-
[Journal Article] A novel split liver protocol using the subnormothermic oxygenated circuit system in a porcine model of a marginal donor procedure.2015
Author(s)
Noriki Okada, Koichi Mizuta, Masamitsu Oshima, Naoya Yamada, Yukihiro Sanada, Yoshiyuki Ihara, Taizen Urahashi, Jun Ishikawa, Takashi Tsuji, Shuji Hishikawa, Takumi Teratani, Eiji Kobayashi
-
Journal Title
Transplantation Proceedings
Volume: 47(2)
Issue: 2
Pages: 419-426
DOI
Related Report
Peer Reviewed
-
[Presentation] Amino acid metabolism as viability assessment of liver grafts in a porcine model during ex vivo normothermic machine perfusion2016
Author(s)
Noriki Okada, Koichi Mizuta, Masamitsu Oshima, Takumi Katano, Yuta Hirata, Naoya Yamada, Yukihiro Sanada, Yoshiyuki Ihara, Taizen Urahashi, Jun Ishikawa, Takashi Tsuji, Shuji Hishikawa, Takumi Teratani, Eiji Kobayashi
Organizer
The Transplantation Society
Place of Presentation
Hong Kong
Year and Date
2016-08-19
Related Report
Int'l Joint Research