Functional analysis of fuctional RNA involvement in colorectal cancer development and progression
| Project/Area Number |
26861104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
TAKAHASHI Rina 順天堂大学, 医学部, 非常勤助手 (80639112)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | メチルトランスフェラーゼ / non-coding RNA / エピジェネティクス / 大腸癌 / 機能性RNA / イントロニックRNA / SMYD3 |
|---|
| Outline of Final Research Achievements |
SMYD3 plays a crucial role in carcinogenesis. The intronic SMYD3 RNAis excised in intron of SMYD3 gene and control the expression of SMYD3. The role of intronic SMYD3 in colorectal cancer is largely unknown. To uncover the function of intronic SMYD3 RNA, in situ hybridization for intronic SMYD3 RNA were carried out using tissue microarray constructed from colorectal cancer samples. As a result, there was a decrease trend in its expression in metastatic colorectal cancer. Then I tried to establish the colorectal cancer cell lines which deleted intronic SMYD3 RNA. In further study, I will investigate whether intronic SMYD3 RNA are involved in metastasis or not using model organism and cancer cell lines.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] A case of metastatic carcinoma of anal fistula caused by implantation from rectal cancer2015
Author(s)
Rina Takahashi, Ryosuke Ichikawa, Singo Ito, Kosuke Mizukoshi, Shun Ishiyama, Kiichi Sgimoto, Yutaka Kojima, Michitoshi Goto, Yuichi Tomiki, Takashi Yao, Kazuhiro Sakamoto :
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Journal Title
Surgical Case Reports
Volume: 123
Issue: 1
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Case of Clear Cell Adenocarcinoma Arising from Endometriosis of the Rectum Treated by Laparoscopic Surgery2014
Author(s)
Yu Okazawa, Rina Takahashi, Kosuke Mizukoshi, Kazuhiro Takehara, Shun Ishiyama, Kiichi Sugimoto, Makoto Takahashi, Yutaka Kojima, michitoshi Goto, Atsushi Okuzawa, Yuichi Tomiki, Takashi Yao, Kazuhiro Sakamoto
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Journal Title
nternational Journal of Surgery Case Reports
Volume: 5
Issue: 12
Pages: 979-983
DOI
Related Report
Open Access
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[Presentation] Laparoscopic Sigmoid Colon Resection by Use of Needle Forceps and Transanal Specimen Extraction2016
Author(s)
Rina Takahashi, Kazuhiro Sakamoto, Yuichi Tomiki, Atsushi Okuzawa, Michitoshi Goto,Yutaka Kojia, Hirohiko ,Shun Ishiyama, Kiichi Sugimoto, Hisashi R
Organizer
15th World Congress of Endoscopic Surgery
Place of Presentation
Shanghai-Suzhou, China
Year and Date
2016-11-09
Related Report
Int'l Joint Research
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