Development of the combined immunotherapy using novel immunoregulatory cells for malignant pleural mesothelioma

• Project/Area Number: 26861118
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kyushu University
• Principal Investigator: TAGAWA Tetsuzo 九州大学, 大学病院, 助教 (90419557)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 悪性腫瘍 / 薬物療法 / 免疫療法 / 悪性胸膜中皮腫 / 肺癌 / 呼吸器外科 / 腫瘍浸潤リンパ球 / 胸水

Outline of Final Research Achievements

The purpose of the present study is to elucidate the impact of immune-regulatory cells (MDSC) in the pathogenesis of malignant pleural mesothelioma (MPM) and to demonstrate the possibility of novel immunotherapy for MPM using MDSC.
By using an intrathoracic murine MPM model, we found that the number of MDSC increased in the pleural effusion after intrathoracic tumor cell injection. We also demonstrated that there are significant amount of MDSC in the pleural effusion of the MPM patient. In addition, we elucidated that c-reactive protein/albumin ratio which combines patient’s immune and nutritional status is a novel prognostic marker in MPM patients. These results suggest that novel immunotherapy targeting immuno-regulatory cells such as MDSC may be useful for MPM.

Research Products

• [Journal Article] The C-Reactive Protein/Albumin Ratio is a Novel Significant Prognostic Factor in Patients with Malignant Pleural Mesothelioma: A Retrospective Multi-institutional Study (2018)
  • Author(s): Takamori Shinkichi、Toyokawa Gouji、Shimokawa Mototsugu、Kinoshita Fumihiko、Kozuma Yuka、Matsubara Taichi、Haratake Naoki、Akamine Takaki、Hirai Fumihiko、Seto Takashi、Tagawa Tetsuzo、Takenoyama Mitsuhiro、Ichinose Yukito、Maehara Yoshihiko
  • Journal Title: Annals of Surgical Oncology Volume: 25 Issue: 6 Pages: 1555-1563
  • DOI: 10.1245/s10434-018-6385-x
  • Peer Reviewed
• [Presentation] The C-reactive Protein/Albumin Ratio is a Novel Significant Prognostic factor in Patients with Malignant Pleural Mesothelioma (2017)
  • Author(s): Takamori S., Toyokawa G., Tagawa T., Kinoshita F., Kozuma Y., Matsubara T., Haratake N., Akamine T., Hirai F., Takenoyama M, Ichinose Y., Maehara Y.
  • Organizer: 18th World Conference on Lung Cancer
  • Int'l Joint Research
• [Presentation] 術前Controlling Nutritional Status(CONUT)は胸膜悪性中皮腫患者における術後の予後予測因子である (2017)
  • Author(s): 髙森 信吉、豊川 剛二、木下 郁彦、松原 太一、上妻 由佳、原武 直紀、赤嶺 貴紀、平井 文彦、庄司 文裕、田川 哲三、岡本 龍郎、竹之山 光広、一瀬 幸人、前原 喜彦
  • Organizer: 第117回日本外科学会定期学術集会