| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The purpose of the present study is to elucidate the impact of immune-regulatory cells (MDSC) in the pathogenesis of malignant pleural mesothelioma (MPM) and to demonstrate the possibility of novel immunotherapy for MPM using MDSC.
By using an intrathoracic murine MPM model, we found that the number of MDSC increased in the pleural effusion after intrathoracic tumor cell injection. We also demonstrated that there are significant amount of MDSC in the pleural effusion of the MPM patient. In addition, we elucidated that c-reactive protein/albumin ratio which combines patient’s immune and nutritional status is a novel prognostic marker in MPM patients. These results suggest that novel immunotherapy targeting immuno-regulatory cells such as MDSC may be useful for MPM.
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