Evaluation of Donor Lung Function using High-flow Perfusion Model during Ex Vivo Lung Perfusion

• Project/Area Number: 26861120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Niigata University
• Principal Investigator: Terumoto Koike 新潟大学, 医歯学系, 講師 (90635723)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 肺移植 / 生体外肺還流 / EVLP

Outline of Final Research Achievements

We tried to evaluate the Po2 level in the perfusate during the Ex vivo Lung Perfusion of the high perfusion flow to detect donor lung injury more precisely compared to the standard protective setting ot the low perfusion flow. At the high flow of 100% (250% of the standard setting) of the estimated cardiac output, the Po2 level was not decreased. Because of the setting of the perfusion circuit, we could not get the high flow of >200%.