| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Controlling invasiveness is a pivotal concept to conquer cancers. We selected guanylate binding protein 1 (GBP-1) as a candidate molecule involved in invasion of lung adenocarcinoma for further analyses. Human lung adenocarcinoma samples showed higher GBP-1level, while higher expression of GBP-1 was detected in mesenchymal-like cells than epithelial-like cells. Then, cell motility assay provided the evidence of involvement of GBP-1 in promoting lung adenocarcinoma cell motility. In addition, clinicopathological findings including immunohistochemistry for GBP-1 of patients with lung adenocarcinoma revealed the positive association between GBP-1 expression and lymph-vascular invasion.
In conclusion, GBP-1 induces invasiveness of early stage lung adenocarcinoma through promoting cell motility. And might contribute to the development of new therapeutic strategies for lung adenocarcinoma.
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