Lung cancer metastasizes to lymph nodes by stromal cells

Research Project

Project/Area Number	26861126
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Respiratory surgery
Research Institution	Keio University
Principal Investigator	Otake Sotaro 慶應義塾大学, 医学部(信濃町), 助教 (70649954)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	肺癌 / 腫瘍免疫 / ストローマ細胞 / 肺癌リンパ節転移 / 癌転移モデル
Outline of Final Research Achievements	The purpose of this study is to make the animal model of lymph node metastasis from lung cancer, and to detect and analyze immune cells and stromal cells in lymph node metastasis. First, we made the mouse model of lymph node metastasis from lung cancer using Lewis lung cancer. Then, We investigated this lymph node metastasis. This model may show an early change in lymph node metastasis from lung cancer.