The effect of PPAR gamma ligand in bronchiolitis obliterans in a mouse tracheal transplant model study
| Project/Area Number |
26861127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
Ohtsuka Takashi
Shimoda Masayuki
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺移植 / 拒絶反応 / PPARγ / Pioglitazone / BOS / マウス気管移植モデル |
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| Outline of Final Research Achievements |
The administration of pioglitazone, a PPAR gamma agonist, leads to a decrease in tracheal allograft luminal occlusions and the induction of regulatory T cell accumulation in the allograft in a mouse tracheal transplantation model. This indicates a protective role of pioglitazone against bronchiolitis obliterans. The potential mechanism of these effects includes a decrease in inflammatory cytokine production. However, the anti-inflammatory potential, and efficacy in the maintenance of transplant tolerance needs to be validated in the future.
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Report
(3 results)
Research Products
(3 results)
