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The effect of PPAR gamma ligand in bronchiolitis obliterans in a mouse tracheal transplant model study

Research Project

Project/Area Number 26861127
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionKeio University

Principal Investigator

Shigenobu Takao  慶應義塾大学, 医学部, 助教 (50626702)

Research Collaborator Ohtsuka Takashi  
Shimoda Masayuki  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺移植 / 拒絶反応 / PPARγ / Pioglitazone / BOS / マウス気管移植モデル
Outline of Final Research Achievements

The administration of pioglitazone, a PPAR gamma agonist, leads to a decrease in tracheal allograft luminal occlusions and the induction of regulatory T cell accumulation in the allograft in a mouse tracheal transplantation model. This indicates a protective role of pioglitazone against bronchiolitis obliterans. The potential mechanism of these effects includes a decrease in inflammatory cytokine production. However, the anti-inflammatory potential, and efficacy in the maintenance of transplant tolerance needs to be validated in the future.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015

All Presentation (3 results)

  • [Presentation] Pioglitazone投与による気管移植動物モデルの拒絶反応抑制、FoxP3陽性細胞の集積2015

    • Author(s)
      重信敬夫
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pioglitazone投与による気管移植動物モデルの拒絶反応抑制、FoxP3陽性細胞の集積2015

    • Author(s)
      重信敬夫
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Pioglitazoneによる気管移植モデルの拒絶反応抑制2015

    • Author(s)
      重信敬夫
    • Organizer
      第31回日本肺および心肺移植研究会
    • Place of Presentation
      東京大学山上会館大会議室
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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