Innovation of cancer therapies based on anti-aging klotho gene

• Project/Area Number: 26861129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: KUDO YUJIN 東京医科大学, 医学部, 助教 (80623800)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: klotho / アンチエイジング / 肺癌 / 予後 / 再発 / 補助化学療法 / タキサン系抗癌剤

Outline of Final Research Achievements

We reported that the klotho gene, which was an anti-aging gene, affected the prognosis of lung cancer patients. We also found that a high expression of the klotho protein could markedly increase the apoptotic response of cancer cells to taxanes, anti-cancer agents. The expression of klotho protein was not associated with those of class III β-tubulin and P glycoprotein. Klotho expression was a significant prognostic factor in patients with pN2 lung cancer, and those without klotho expression had worse survival than those with klotho expression. The potential for high-grade malignancy was also investigated in patients who underwent surgical resection for lung cancer or those with postoperative recurrence.

Research Products

• [Journal Article] Association between high-resolution computed tomography findings and the IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients. (2015)
  • Author(s): Kudo Y, Matsubayashi J, Saji H, Akata S, Shimada Y, Kato Y, Kakihana M, Kajiwara N, Ohira T, Nagao T, Ikeda N.
  • Journal Title: Lung Cancer Volume: 90 Issue: 1 Pages: 47-54
  • DOI: 10.1016/j.lungcan.2015.07.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic factors for survival after recurrence in patients with completely resected lung adenocarcinoma: important roles of epidermal growth factor receptor mutation status and current staging system (2015)
  • Author(s): Yujin Kudo, Yoshihisa Shimada, Hisashi Saji, Yasufumi Kato, Koichi Yoshida, Jun Matsubayashi, Seisuke Nagase, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Toshitaka Nagao, Norihiko Ikeda
  • Journal Title: Clinical Lung Cancer Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 小型肺腺癌におけるHRCT所見とIASLC/ATS/ERS分類を用いた臨床病理学的因子の関係 (2015)
  • Author(s): 工藤勇人,松林純,赤田壮一,嶋田善久,雨宮亮介,加藤靖文,垣花昌俊,梶原直央,大平達夫,池田徳彦
  • Organizer: 第56回日本肺癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-26
• [Presentation] Klotho expression induces apoptosis of cancer cells against anti-cancer agents (2015)
  • Author(s): Yujin Kudo, Jitsuo Usuda, Junichiro Osawa, Shotaro Ono, Sachio Maehara, Keishi Ohtani, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 3rd International Conference of Federation of Asian Clinical Oncology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2015-10-29
  • Int'l Joint Research
• [Presentation] 肺扁平上皮癌においてリンパ節転移が予後に与える影響 (2015)
  • Author(s): 工藤勇人、嶋田善久、雨宮亮介、前田純一、吉田浩一、加藤靖文、萩原優、垣花昌俊、梶原直央、 大平達夫、池田徳彦
  • Organizer: 第68回日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-19
• [Presentation] Adjuvant chemotherapy for stage IB non-small cell lung cancer based on blood vessel invasion (2015)
  • Author(s): Yujin Kudo, Yoshihisa Shimada, Ryosuke Amemiya, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 29th European Association for Cardio-Thoracic Surgery Annual Meeting
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-10-06
  • Int'l Joint Research
• [Presentation] Impact of lymph node involvement on survival in patients with completely resected pulmonary squamous cell carcinoma (2015)
  • Author(s): Yujin Kudo, Yoshihisa Shimada, Ryosuke Amemiya, Junichi Maeda, Koichi Yoshida, Yasufumi Kato, Masaru Hagiwara, Jun Matsubayashi, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: 16th IASLC World Conference on Lung Cancer
  • Place of Presentation: Denver, USA
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Correlation between high-resolution computed tomography findings and IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients (2015)
  • Author(s): Yujin Kudo, Jun Matsubayashi, Yoshihisa Shimada, Soichi Akata, Yasufumi Kato, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Toshitaka Nagao, Norihiko Ikeda
  • Organizer: 2015 ASCO Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-06-01
• [Presentation] 30mm以下の肺腺癌における術前HRCT所見とIASLC/ATS/ERS分類を用いた臨床病理学的因子の関係 (2015)
  • Author(s): 工藤勇人、嶋田善久、雨宮亮介、加藤靖文、垣花昌俊、梶原直央、大平達夫、池田徳彦
  • Organizer: 第32回日本呼吸器外科学会総会
  • Place of Presentation: 高松
  • Year and Date: 2015-05-15
• [Presentation] 若年者肺癌切除例の臨床病理学的特徴と予後 (2014)
  • Author(s): 工藤勇人，嶋田善久，河口洋平，大谷圭志，垣花昌俊，加藤靖文，梶原直央，大平達夫，池田徳彦
  • Organizer: 第55回日本肺癌学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-14
• [Presentation] Impact of EGFR mutation status on survival after recurrence in patients with completely resected lung adenocarcinoma (2014)
  • Author(s): Kudo Y, Shimada Y, Kato Y, Yoshida K, Osawa J, Maehara S, Maeda J, Matsybayashi J, Kakihana M, Kajiwara N, Ohira T, Ikeda N
  • Organizer: 2014 IASLC Asia Pacific Lung Cancer Conference
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-06
• [Presentation] 肺腺癌切除後再発とEGFR遺伝子変異の関係 (2014)
  • Author(s): 工藤勇人，嶋田善久，垣花昌俊，大谷圭志，加藤靖文，佐治久，梶原直央，大平達夫，池田徳彦
  • Organizer: 第67回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-10-03