Carcinogenesis in lung cancer with idiopathic pulmonary fibosis related to MUC expresion

• Project/Area Number: 26861130
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: Shimada Yoshihisa 東京医科大学, 医学部, 助教 (00459497)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺癌 / 肺線維症 / 癌化機構 / 粘液過剰産生 / 発癌機構 / 粘液蛋白 / 間質性肺炎 / ムチン遺伝子

Outline of Final Research Achievements

Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. IPF was also reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy.Clinical and physiological parameters to predict how rapidly patients with IPF might progress, genetic and molecular features are also associated with IPF mortality. It has been shown that IPF patients who have a specific genotype in the mucin MUC5B gene polymorphism experience significantly improved survival. The purpose of this study is to assess the impact of mucin overproduction mechanism potenitially involved in carcinogenesis in lung cancer.

Research Products

• [Journal Article] (5)The frequency and prognostic impact of pathological microscopic vascular invasion according to tumor size in non-small cell lung cancer. (2016)
  • Author(s): Ｙｏｓｈｉｈｉｓａ Ｓｈｉｍａｄａ
  • Journal Title: ＣＨＥＳＴ Volume: 3 Pages: 775-785
  • Peer Reviewed / Acknowledgement Compliant