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ANP-mediated vasoprotective action against cancer metastasis

Research Project

Project/Area Number 26861136
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Nojiri Takashi  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50570553)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsナトリウム利尿ペプチド / 癌転移 / がん再発 / 抗転移療法 / 手術療法 / 心房性ナトリウム利尿ペプチド / 血管 / 肺外科
Outline of Final Research Achievements

We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. In addition, we demonstrated that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). We showed that ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (13 results) (of which Int'l Joint Research: 2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 肺癌手術におけるBNP診断とANP治療-血管保護作用による癌転移抑制効果の発見-2015

    • Author(s)
      野尻崇、奥村明之進、寒川賢治
    • Journal Title

      呼吸

      Volume: 34 Pages: 954-959

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心房性ナトリウム利尿ペプチドの血管保護作用による癌転移予防効果-機序解明に向けて-2015

    • Author(s)
      野尻崇、徳留健、細田洋司、三浦浩一、宮里幹也、寒川賢治
    • Journal Title

      血管

      Volume: 38 Pages: 109-114

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANPのがん転移阻止のトランスレーショナルリサーチ2015

    • Author(s)
      野尻崇、寒川賢治
    • Journal Title

      Medical Science Digest

      Volume: 41 Pages: 500-503

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANPの血管保護作用による癌転移抑制効果-国循主導世界初の臨床研究に向けて-2015

    • Author(s)
      野尻崇、奥村明之進、宮里幹也、寒川賢治
    • Journal Title

      循環器病研究の進歩

      Volume: 36 Pages: 65-73

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 13 Pages: 4086-4091

    • DOI

      10.1073/pnas.1417273112

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury2014

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Kimura T, Shintani Y, Inoue M, Sawabata N, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 29 Issue: 1 Pages: 24-30

    • DOI

      10.1016/j.pupt.2014.01.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury2014

    • Author(s)
      Nojiri T, Hosoda H, Kimura T, Miura K, Ishikane S, Tokudome T, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 75 Issue: 1 Pages: 123-129

    • DOI

      10.1007/s00280-014-2624-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ANPの血管保護作用による癌転移抑制効果-前向き多施設臨床研究(JANP study)開始-2015

    • Author(s)
      野尻崇、奥村明之進、寒川賢治
    • Organizer
      第19回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ANPの血管保護作用による肺癌術後再発予防効果-前向き多施設臨床研究(JANP study)開始に向けて-2015

    • Author(s)
      野尻崇、新谷康、井上匡美、南正人、寒川賢治、奥村明之進
    • Organizer
      第56回日本肺癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] ANPの血管保護作用による術後再発予防効果-前向き多施設臨床研究開始に向けて-2015

    • Author(s)
      野尻崇、細田洋司、徳留健、三浦浩一、新谷康、木村亨、井上匡美、南正人、竹内幸康、前田元、宮里幹也、寒川賢治、奥村明之進
    • Organizer
      第53回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] BNP-guided risk assessment and ANP treatment for lung cancer surgery2015

    • Author(s)
      Nojiri T, Okumura M.
    • Organizer
      第68回日本胸部外科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery2015

    • Author(s)
      Nojiri T, Inoue M, Shintani Y, Takeuchi Y, Maeda H, Hamasaki T, Okumura M.
    • Organizer
      16th World Conference on Lung Cancer
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical Significance of Atrial Natriuretic Peptide in Cancer Recurrence following Cancer Surgery2015

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Kimura T, Okumura M, Kangawa K.
    • Organizer
      7th International Conference on cGMP
    • Place of Presentation
      Trier, Germany
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ANPの血管保護作用による新しい癌転移予防戦略 -前向き多施設臨床研究に向けて-2015

    • Author(s)
      野尻崇、新谷康、井上匡美、南正人、別所俊哉、舟木壮一郎、川村知裕、竹内幸康、前田元、奥村明之進
    • Organizer
      第32回日本呼吸器外科学会総会
    • Place of Presentation
      高松
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心房性ナトリウム利尿ペプチドの固形癌に対する肺転移抑制効果2014

    • Author(s)
      野尻崇、細田洋司、徳留健、三浦浩一、石兼真、木村亨、望月直樹、宮里幹也、奥村明之進、寒川賢治
    • Organizer
      第18回日本心血管内分泌代謝学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 心房性ナトリウム利尿ペプチドの固形癌に対する肺転移抑制効果-臨床応用に向けて-2014

    • Author(s)
      野尻崇、新谷康、木村亨、井上匡美、寒川賢治、奥村明之進
    • Organizer
      第55回日本肺癌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Atrial natriuretic peptide prevents cancer metastasis through inhibition of cancer cell adhesion to vascular endothelial cells2014

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Kishimoto I, Miura K, Mochizuki N, Miyazato M, Okumura M, Kangawa K.
    • Organizer
      The Conference on Bioactive Peptides for Cell-Cell Communication 2014
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 心房性ナトリウム利尿ペプチドの血管保護作用による癌転移予防効果-機序解明に向けて-2014

    • Author(s)
      野尻崇、細田洋司、徳留健、三浦浩一、木村亨、井上匡美、新谷康、南正人、澤端章好、竹内幸康、前田元、宮里幹也、望月直樹、奥村明之進、寒川賢治
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical significance of atrial natriuretic peptide in cancer metastasis2014

    • Author(s)
      Nojiri T, Hosoda H, Tokudome T, Miyazato M, Shintani Y, Inoue M, Takeuchi Y, Maeda H, Kangawa K, Okumura M.
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 心房性ナトリウム利尿ペプチドの血管保護作用による新しい癌転移予防戦略2014

    • Author(s)
      野尻崇、細田洋司、徳留健、三浦浩一、石兼真、井上匡美、新谷康、木村亨、南正人、澤端章好、中桐伴行、舟木壮一郎、竹内幸康、前田元、宮里幹也、望月直樹、寒川賢治、奥村明之進
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Remarks] 心臓ホルモンによるがん転移抑制効果についての多施設臨床研究開始

    • URL

      http://www.ncvc.go.jp/pr/release/janp.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 心臓ホルモンによるがん転移予防効果のメカニズムの解明、並びに多施設臨床研究開始のお知らせ

    • URL

      http://www.ncvc.go.jp/pr/release/007403.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] NPR-Aアゴニスト及び微小管阻害作用を有する化合物を組み合わせてなる医薬2015

    • Inventor(s)
      寒川賢治、野尻崇、細田洋司
    • Industrial Property Rights Holder
      寒川賢治、野尻崇、細田洋司
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-222136
    • Filing Date
      2015-11-12
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2023-03-23  

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