ANP-mediated vasoprotective action against cancer metastasis

• Project/Area Number: 26861136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Nojiri Takashi 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50570553)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ナトリウム利尿ペプチド / 癌転移 / がん再発 / 抗転移療法 / 手術療法 / 心房性ナトリウム利尿ペプチド / 血管 / 肺外科

Outline of Final Research Achievements

We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. In addition, we demonstrated that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). We showed that ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells.

Research Products

• [Journal Article] 肺癌手術におけるBNP診断とANP治療－血管保護作用による癌転移抑制効果の発見－ (2015)
  • Author(s): 野尻崇、奥村明之進、寒川賢治
  • Journal Title: 呼吸 Volume: 34 Pages: 954-959
  • Peer Reviewed
• [Journal Article] 心房性ナトリウム利尿ペプチドの血管保護作用による癌転移予防効果－機序解明に向けて－ (2015)
  • Author(s): 野尻崇、徳留健、細田洋司、三浦浩一、宮里幹也、寒川賢治
  • Journal Title: 血管 Volume: 38 Pages: 109-114
  • Peer Reviewed
• [Journal Article] ANPのがん転移阻止のトランスレーショナルリサーチ (2015)
  • Author(s): 野尻崇、寒川賢治
  • Journal Title: Medical Science Digest Volume: 41 Pages: 500-503
  • Peer Reviewed
• [Journal Article] ANPの血管保護作用による癌転移抑制効果－国循主導世界初の臨床研究に向けて－ (2015)
  • Author(s): 野尻崇、奥村明之進、宮里幹也、寒川賢治
  • Journal Title: 循環器病研究の進歩 Volume: 36 Pages: 65-73
  • Peer Reviewed
• [Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (2015)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
  • Journal Title: Proc Natl Acad Sci USA Volume: 112 Issue: 13 Pages: 4086-4091
  • DOI: 10.1073/pnas.1417273112
  • Peer Reviewed / Open Access
• [Journal Article] Atrial natriuretic peptide inhibits lipopolysaccharide-induced acute lung injury (2014)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Kimura T, Shintani Y, Inoue M, Sawabata N, Miyazato M, Okumura M, Kangawa K
  • Journal Title: Pulm Pharmacol Ther Volume: 29 Issue: 1 Pages: 24-30
  • DOI: 10.1016/j.pupt.2014.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Atrial natriuretic peptide protects against cisplatin-induced acute kidney injury (2014)
  • Author(s): Nojiri T, Hosoda H, Kimura T, Miura K, Ishikane S, Tokudome T, Shintani Y, Inoue M, Miyazato M, Okumura M, Kangawa K
  • Journal Title: Cancer Chemother Pharmacol Volume: 75 Issue: 1 Pages: 123-129
  • DOI: 10.1007/s00280-014-2624-4
  • Peer Reviewed / Open Access
• [Presentation] ANPの血管保護作用による癌転移抑制効果－前向き多施設臨床研究(JANP study)開始－ (2015)
  • Author(s): 野尻崇、奥村明之進、寒川賢治
  • Organizer: 第19回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-10
• [Presentation] ANPの血管保護作用による肺癌術後再発予防効果－前向き多施設臨床研究（JANP study）開始に向けて－ (2015)
  • Author(s): 野尻崇、新谷康、井上匡美、南正人、寒川賢治、奥村明之進
  • Organizer: 第56回日本肺癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-26
• [Presentation] ANPの血管保護作用による術後再発予防効果－前向き多施設臨床研究開始に向けて－ (2015)
  • Author(s): 野尻崇、細田洋司、徳留健、三浦浩一、新谷康、木村亨、井上匡美、南正人、竹内幸康、前田元、宮里幹也、寒川賢治、奥村明之進
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-29
• [Presentation] BNP-guided risk assessment and ANP treatment for lung cancer surgery (2015)
  • Author(s): Nojiri T, Okumura M.
  • Organizer: 第68回日本胸部外科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-17
• [Presentation] Impact of Postoperative Complications on Cancer Recurrence Following Lung Cancer Surgery (2015)
  • Author(s): Nojiri T, Inoue M, Shintani Y, Takeuchi Y, Maeda H, Hamasaki T, Okumura M.
  • Organizer: 16th World Conference on Lung Cancer
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] Clinical Significance of Atrial Natriuretic Peptide in Cancer Recurrence following Cancer Surgery (2015)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Kimura T, Okumura M, Kangawa K.
  • Organizer: 7th International Conference on cGMP
  • Place of Presentation: Trier, Germany
  • Year and Date: 2015-06-19
  • Int'l Joint Research
• [Presentation] ANPの血管保護作用による新しい癌転移予防戦略 －前向き多施設臨床研究に向けて－ (2015)
  • Author(s): 野尻崇、新谷康、井上匡美、南正人、別所俊哉、舟木壮一郎、川村知裕、竹内幸康、前田元、奥村明之進
  • Organizer: 第32回日本呼吸器外科学会総会
  • Place of Presentation: 高松
  • Year and Date: 2015-05-14
• [Presentation] 心房性ナトリウム利尿ペプチドの固形癌に対する肺転移抑制効果 (2014)
  • Author(s): 野尻崇、細田洋司、徳留健、三浦浩一、石兼真、木村亨、望月直樹、宮里幹也、奥村明之進、寒川賢治
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 心房性ナトリウム利尿ペプチドの固形癌に対する肺転移抑制効果－臨床応用に向けて－ (2014)
  • Author(s): 野尻崇、新谷康、木村亨、井上匡美、寒川賢治、奥村明之進
  • Organizer: 第55回日本肺癌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Atrial natriuretic peptide prevents cancer metastasis through inhibition of cancer cell adhesion to vascular endothelial cells (2014)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Kishimoto I, Miura K, Mochizuki N, Miyazato M, Okumura M, Kangawa K.
  • Organizer: The Conference on Bioactive Peptides for Cell-Cell Communication 2014
  • Place of Presentation: Kyoto
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] 心房性ナトリウム利尿ペプチドの血管保護作用による癌転移予防効果－機序解明に向けて－ (2014)
  • Author(s): 野尻崇、細田洋司、徳留健、三浦浩一、木村亨、井上匡美、新谷康、南正人、澤端章好、竹内幸康、前田元、宮里幹也、望月直樹、奥村明之進、寒川賢治
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] Clinical significance of atrial natriuretic peptide in cancer metastasis (2014)
  • Author(s): Nojiri T, Hosoda H, Tokudome T, Miyazato M, Shintani Y, Inoue M, Takeuchi Y, Maeda H, Kangawa K, Okumura M.
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 心房性ナトリウム利尿ペプチドの血管保護作用による新しい癌転移予防戦略 (2014)
  • Author(s): 野尻崇、細田洋司、徳留健、三浦浩一、石兼真、井上匡美、新谷康、木村亨、南正人、澤端章好、中桐伴行、舟木壮一郎、竹内幸康、前田元、宮里幹也、望月直樹、寒川賢治、奥村明之進
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05
• [Remarks] 心臓ホルモンによるがん転移抑制効果についての多施設臨床研究開始
  • URL: http://www.ncvc.go.jp/pr/release/janp.html
• [Remarks] 心臓ホルモンによるがん転移予防効果のメカニズムの解明、並びに多施設臨床研究開始のお知らせ
  • URL: http://www.ncvc.go.jp/pr/release/007403.html
• [Patent(Industrial Property Rights)] NPR-Aアゴニスト及び微小管阻害作用を有する化合物を組み合わせてなる医薬 (2015)
  • Inventor(s): 寒川賢治、野尻崇、細田洋司
  • Industrial Property Rights Holder: 寒川賢治、野尻崇、細田洋司
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-222136
  • Filing Date: 2015-11-12