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Development of stent to treat vertebral artery dissection: achievement of curability and functional preservation

Research Project

Project/Area Number 26861138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

ENDO Hidenori  東北大学, 医学系研究科, 非常勤講師 (40723458)

Research Collaborator SUGIYAMA Shinichiro  東北大学, 医学系研究科, 非常勤講師 (30623152)
NIIZUMA Kuniyasu  東北大学, 医学系研究科, 助教 (10643330)
NAKAI Masaaki  近畿大学, 理工学部, 准教授 (20431603)
NAKAGAWA Atsuhiro  東北大学, 医学系研究科, 講師 (10447162)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳動脈解離 / 穿通枝 / 脳血管内治療 / ステント / 流体力学 / 数値流体力学
Outline of Final Research Achievements

Fifteen cases with ruptured vertebral artery dissection admitted to our institution between 2014 and 2016. All the cases were examined by cerebral angiography, and the anatomical morphological features of the dissected segment were analyzed. Furthermore, computational fluid dynamics (CFD) of the dissected segment was assessed, based on the data obtained from cerebral angiography. We studied the appropriate condition to preserve the perforators arising from the dissected segment using the CFD technique. We created the new design of stent in the computer simulation, however, these stents did not apply to the real clinical situation, because there were too many morphological and anatomical variations of the dissected segment.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern.2017

    • Author(s)
      Endo H, Osawa SI, Matsumoto Y, Endo T, Sato K, Niizuma K, Fujimura M, Tominaga T.
    • Journal Title

      Neurosurg Rev.

      Volume: 印刷中 Issue: 1 Pages: 173-182

    • DOI

      10.1007/s10143-017-0832-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of actuator-driven pulsed water jet in aneurysmal subarachnoid hemorrhage surgery: its effectiveness for dissection around ruptured aneurysmal walls and subarachnoid clot removal.2017

    • Author(s)
      Endo H, Endo T, Nakagawa A, Fujimura M, Tominaga T.
    • Journal Title

      Neurosurg Rev.

      Volume: 印刷中 Issue: 3 Pages: 485-493

    • DOI

      10.1007/s10143-016-0809-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 内頚動脈前壁チマメ状動脈瘤に対する血行再建術の治療成績.2016

    • Author(s)
      遠藤英徳、藤村幹、清水宏明、遠藤俊毅、 井上敬、藤原悟、冨永悌二
    • Organizer
      第39回 東北脳血管障害研究会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 内頚動脈前壁チマメ状動脈瘤に対する血行再建術の治療成績.2016

    • Author(s)
      遠藤英徳、藤村幹、清水宏明、遠藤俊毅、井上敬、藤原悟、冨永悌二
    • Organizer
      第75回 日本脳神経外科学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cerebral blood flow after acute bypass with parent artery occlusion in patients with unclippable ruptured internal carotid artery aneurysms.2016

    • Author(s)
      Hidenori Endo, Miki Fujimura, Hiroaki Shimizu, Kenichi Sato, Takashi Inoue, Teiji Tominaga
    • Organizer
      The7th international Mt.Bandai symposium for Neuroscience
    • Place of Presentation
      Phnom Penh Hotel(Cambodia,プノンペン)
    • Year and Date
      2016-04-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surgical and endovascular treatment for vertebral artery dissection2014

    • Author(s)
      Endo H, Matsumoto Y, Fujimura M, Tominaga T.
    • Organizer
      The 4th X-pert Neurovascular Symposium in KNUH
    • Place of Presentation
      Kyungpook national university(Daegu, Korea)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] PICA involved typeの出血性椎骨動脈解離に対する外科治療2014

    • Author(s)
      遠藤英徳、藤村幹、清水宏明、佐藤健一、松本康史、大沢伸一郎、藤原悟、冨永悌二
    • Organizer
      第73回日本脳神経外科学会学術総会(シンポジウム)
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Preservation of the perforators in the internal trapping of a ruptured vertebral artery dissection2014

    • Author(s)
      Endo H, Matsumoto Y, Sato K, Fujimura M, Shimizu H, Fujiwara S, Tominaga T.
    • Organizer
      The 12th Korean and Japanese Friendship Conference on Surgery for Cerebral Stroke
    • Place of Presentation
      梅田スカイビル(大阪府大阪市)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Book] 前交通動脈瘤・椎骨動脈瘤のすべて2016

    • Author(s)
      遠藤英徳
    • Total Pages
      4
    • Publisher
      メディカ出版
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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