| Project/Area Number |
26861141
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
Ogura Ryosuke 新潟大学, 医歯学総合病院, 医員 (70626423)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ボリノスタット / MGMT / 局在 / テモゾロミド / シャペロン介在性オートファジー / 核外移行 |
|---|
| Outline of Final Research Achievements |
Vorinostat, a histone deacetylase inhibitor, suppress O6-methylguanine-DNA methyltransferase (MGMT) activity, but the mechanism is unknown. In this study, we found that it was necessary to resistant to temozolomide that MGMT localized in nucleus. And MGMT overexpression in cytoplasm may be degraded by chaperone-mediated autophagy. It can be new treatment strategy to change MGMT localization by vorinostat.
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