Endogenous secretory RAGE as a potential protective factor against ischemic cerebrovascular diseases
Project/Area Number |
26861143
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Kanazawa University |
Principal Investigator |
Shimizu Yu 金沢大学, 大学病院, 医員 (90646689)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | esRAGE / 神経細胞死 / パラバイオーシス / 血液脳関門 / 脳血液関門 / 脳血管障害 / 虚血 |
Outline of Final Research Achievements |
Receptor for Advanced Glycation End-products (RAGE) is a pattern-recognition receptor and plays a role in the development of neuronal cell death during and after brain ischemia. RAGE has a splicing variant form, which is soluble and named as endogenous secretory RAGE (esRAGE). esRAGE is considered to work as a decoy-type receptor and attenuate ischemia-induced neuronal cell damages. In this study, we proved that esRAGE can be associated with heparan sulphate proteoglycans (HSPG) on brain endothelial cells and act as a potential protective factor against the ischemic cerebrovascular diseases.
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Report
(3 results)
Research Products
(3 results)