| Project/Area Number |
26861146
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | iPS細胞 / ドパミン神経 / パーキンソン病 / 細胞移植治療 / シナプス形成 / ヒトiPS細胞 / エストラジオール / 細胞接着因子 / 神経再生 |
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| Outline of Final Research Achievements |
Cell transplantation therapy using human pluripotent stem cell (PSC)-derived midbrain dopaminergic (mDA) neurons is expected to soon reach Parkinson's disease (PD) patients. Especially, neuronal innervation and functional synaptic formation between grafted-DA neurons and host striatal neurons is crucial for restoring the lost neuronal function of PD patients.
We found that systemic administration of an estradiol derivative, estradiol-2-benzoate (E2B), promotes the activation of integrin α5 and facilitates the behavioral recovery of parkinsonian model rats via the synaptic formation between grafted iPSC-derived DA neurons and host striatal neurons. These findings suggested that systemic administration of E2B provides a microenviromental cue for synaptic formation via activation of integrin α5 in host striatal neurons, thus potentially providing pharmacotheraputic benefit in humans.
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