Evaluation of co-transplantation method between olfactory mucosa transplantation method and bone marrow mesenchymal cell medulla injection therapy
| Project/Area Number |
26861149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Ohnishi Yu-ichiro 大阪大学, 医学系研究科, 助教 (00533811)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | relay neuron / 脊髄損傷 / 嗅粘膜移植 / spinal DTI / fMRI / 神経栄養因子 / 慢性期脊髄損傷 / 神経軸索再生 / relay neurons / neuronal relay formation |
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| Outline of Final Research Achievements |
Bone mesenchymal stem cell (BMSC) was intrathecally administered as a combined therapy for the olfactory mucosal membrane transplantation to the rat spinal cord injury model, and the number of axon relay cells (Relay-neurons) was the main evaluation item did. Relay-neurons play an important role in the concept of neural regeneration after transplantation. However, there is a problem peculiar to the crush model about the contribution degree, and it remains unclear.To clarify the involvement of Relay-neurons, spinal cord DTI in the case showing the recovery of motor function of the lower limb after OM transplantation cases in humans was evaluated, and furthermore in the OM transplantation cases in human , Brain function change accompanying restoration of motor function of the lower extremity was analyzed using fMRI in a patient after OM transplantation and fMRI changes are related to the restoration of the lower limb motor function involved by Relay neurons.
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Report
(4 results)
Research Products
(3 results)
