Expression of oxytocin receptor in a rat stroke model
| Project/Area Number |
26861150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Sugimoto Kana 大阪大学, 医学系研究科, 助教 (00581034)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Yuki 大阪大学, 免疫学フロンティア研究センター, 特任助教 (20443806)
TANAKA Junya 愛媛大学, 大学院医学系研究科, 教授 (70217040)
MATSUMOTO Hiroshi 大阪大学, 大学院医学系研究科, 教授 (60263092)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脳梗塞 / オキシトシン受容体 / オキシトシン |
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| Outline of Final Research Achievements |
In the present study, we evaluated the spatial and time-dependent changes of oxytocin receptor (OXTR) expression on a transient middle cerebral artery occlusion model of rats. Tissues from the cerebral cortex representing the three regions: the ischemic core, the peri-infarct tissue and the contralateral cortex were dissected out at 0.25-7 days postreperfusion (dpr). OXTR mRNA expression peaked at 1 dpr in the peri-infarct tissue. Additionally, in situ hybridization analyses of rat ischemic brain at 1 dpr showed upregulation of OXTR mRNAs in the right cerebrum without ischemic core, especially in the cingulate cortex, piriform cortex and anterior olfactory area. One-dpr expression of OXTR mRNA in this study may be critical for better prognosis following stroke to rescue damaged cells in this region during the subacute phase, leading to be the most effective for neural damage to treat oxytocin within 1 day of stroke onset.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016
Author(s)
Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
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Journal Title
Neurochemistry International
Volume: 99
Pages: 158-168
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016
Author(s)
Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
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Journal Title
Experimental Neurology
Volume: 277
Pages: 150-161
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CD200+ and CD 200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages2015
Author(s)
Shirabe Matsumoto, Junya Tanaka, Hajime Yano, Hisaaki Takahashi, Kana Sugimoto, Shiro Ohue, Akihiro Inoue, Hitomi Aono, Akari Kusakawa, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
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Journal Title
Journal of Neuroimmunology
Volume: 282
Pages: 7-20
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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