• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Expression of oxytocin receptor in a rat stroke model

Research Project

Project/Area Number 26861150
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Sugimoto Kana  大阪大学, 医学系研究科, 助教 (00581034)

Co-Investigator(Renkei-kenkyūsha) MORI Yuki  大阪大学, 免疫学フロンティア研究センター, 特任助教 (20443806)
TANAKA Junya  愛媛大学, 大学院医学系研究科, 教授 (70217040)
MATSUMOTO Hiroshi  大阪大学, 大学院医学系研究科, 教授 (60263092)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳梗塞 / オキシトシン受容体 / オキシトシン
Outline of Final Research Achievements

In the present study, we evaluated the spatial and time-dependent changes of oxytocin receptor (OXTR) expression on a transient middle cerebral artery occlusion model of rats. Tissues from the cerebral cortex representing the three regions: the ischemic core, the peri-infarct tissue and the contralateral cortex were dissected out at 0.25-7 days postreperfusion (dpr). OXTR mRNA expression peaked at 1 dpr in the peri-infarct tissue. Additionally, in situ hybridization analyses of rat ischemic brain at 1 dpr showed upregulation of OXTR mRNAs in the right cerebrum without ischemic core, especially in the cingulate cortex, piriform cortex and anterior olfactory area. One-dpr expression of OXTR mRNA in this study may be critical for better prognosis following stroke to rescue damaged cells in this region during the subacute phase, leading to be the most effective for neural damage to treat oxytocin within 1 day of stroke onset.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (10 results)

  • [Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016

    • Author(s)
      Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
    • Journal Title

      Neurochemistry International

      Volume: 99 Pages: 158-168

    • DOI

      10.1016/j.neuint.2016.06.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016

    • Author(s)
      Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
    • Journal Title

      Experimental Neurology

      Volume: 277 Pages: 150-161

    • DOI

      10.1016/j.expneurol.2015.12.016

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD200+ and CD 200- macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages2015

    • Author(s)
      Shirabe Matsumoto, Junya Tanaka, Hajime Yano, Hisaaki Takahashi, Kana Sugimoto, Shiro Ohue, Akihiro Inoue, Hitomi Aono, Akari Kusakawa, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
    • Journal Title

      Journal of Neuroimmunology

      Volume: 282 Pages: 7-20

    • DOI

      10.1016/j.jneuroim.2015.03.013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G22014

    • Author(s)
      Hosokawa Y, Takahashi H, Inoue A, et al.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1850 Issue: 6 Pages: 1197-1205

    • DOI

      10.1016/j.bbagen.2015.01.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma2014

    • Author(s)
      Takahashi H, Inoue A, Kawabe Y, et al.
    • Journal Title

      Brain Tumor Pathology

      Volume: 32 Issue: 1 Pages: 31-40

    • DOI

      10.1007/s10014-014-0203-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ethanol increases astrocyte aquaporin-4 expression under hyper-sodium condition2014

    • Author(s)
      Ryuichi Katada, Kana Sugimoto, Motonori Yoshida, Hiroshi Matsumoto.
    • Journal Title

      Nihon Arukoru Yakubutsu Igakkai Zasshi

      Volume: 49 Pages: 188-94

    • NAID

      40022403058

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 一過性脳虚血モデルラットにおけるmiRNAの経時・空間的発現変動の網羅的解析2017

    • Author(s)
      杉本香奈,森勇樹,平田雄一郎,鎌倉悠宇,高橋真樹子,片田竜一,松本博志
    • Organizer
      第101次日本法医学会学術全国集会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2017-06-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of oxytocin receptor in ischemic lesions of rat brain: one protective mechanism of oxytocin for injured neurons2017

    • Author(s)
      Kana Sugimoto, Yuki Mori, Hidekazu Tanaka, Yuichiro Hirata, Yu Kamakura, Makiko Takahashi, Ryuichi Katada, Hiroshi Matsumoto
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of oxytocin receptors in the peri-infarct tissue of rat brain: protection of oxytocin for injured neurons2016

    • Author(s)
      Kana Sugimoto, Yuki Mori, Hidekazu Tanaka, Yuichiro Hirata, Yu Kamakura, Ryuichi Katada, Hiroshi Matsumoto
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット脳におけるイオンチャネルの発現量に及ぼすエタノールの影響2016

    • Author(s)
      杉本香奈,片田竜一,田中秀和,平田雄一郎,鎌倉悠宇,吉田原規,高橋真樹子, 望月薫,五十嵐一雄,松本博志
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Transcriptome analysis on ethanol-induced brain injury among primary cultures of brain cells and slices2014

    • Author(s)
      Kana Sugimoto, Hidekazu Tanaka, Ryuichi Katada, Kazuo Igarashi, Motonori Yoshida, Hiroshi Matsumoto
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington (USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] エタノールと向精神薬のラット脳の転写シグナルに及ぼす影響2014

    • Author(s)
      杉本香奈、片田竜一、田中秀和、吉田原規、佐藤崇裕、中間健太郎、吉澤秀憲、五十嵐一雄、松本博志
    • Organizer
      平成26年度 アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Ethanol-induced expression of ion channels in rat brain slices2014

    • Author(s)
      Kana Sugimoto, Hidekazu Tanaka, Ryuichi Katada, Motonori Yoshida, Kazuo Igarashi, Hiroshi Matsumoto
    • Organizer
      16th International Society of Addiction Medicine Annual Meeting
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-10-02 – 2014-10-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of brain cell components in ethanol-induced signal transcription in the brain2014

    • Author(s)
      Kana Sugimoto, Ryuichi Katada, Hidekazu Tanaka, Kazuo Igarashi, Motonori Yoshida, Hiroshi Matsumoto
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] EFFECTS OF ETHANOL AND PSYCHOTROPIC DRUGS ON THE RAT BRAIN2014

    • Author(s)
      Kana Sugimoto, Ryuichi Katada, Motonori Yoshida, Hiroshi Matsumoto
    • Organizer
      37th Research Society on Alcoholism (RSA) & 17th International Society for Biomedical Research on Alcoholism
    • Place of Presentation
      Bellevue (USA)
    • Year and Date
      2014-06-21 – 2014-06-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of ethanol and psychotropic drugs on the signal transcription in the rat brain2014

    • Author(s)
      Kana Sugimoto, Hidekazu Tanaka, Kazuo Igarashi, Motonori Yoshida, Ryuichi Katada, Hiroshi Matsumoto
    • Organizer
      9th International Symposium on Advances in Legal Medicine
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-06-18
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi