Can DBS treat severe depression?
Project/Area Number |
26861151
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Okayama University |
Principal Investigator |
Kameda Masahiro 岡山大学, 医歯薬学総合研究科, 助教 (50586427)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | LTP / DBS / depression / ischemia / 海馬 / neurogenesis / うつ病 / 電気刺激 |
Outline of Final Research Achievements |
The immobile time in forced swim test (FST) in Wistar- Kyoto rats (WKR) was longer than that in Wistar rats (WR). FST in WKR did not affect neurogenesis in hippocampus, which was why WKR is a suitable model for depression experiment. The invasiveness of deep brain stimulation (DBS) examined by 6-OHDA injection using by Hamilton syringe. Based on the result of oxidative stress and antioxidative capacity, the invasiveness of DBS was acceptable. Using bilateral common carotid artery occlusion (2VO) model of WR, DBS was performed on unilateral perforant pathway. DBS enhanced neurogenesis after ischemia induction, and especially, most enhanced neurogenesis was seen in LPT induced WR. We would like to confirm the effect of LTP in WKR.
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Report
(4 results)
Research Products
(202 results)
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[Journal Article] Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease.2016
Author(s)
Sasaki, T., Liu, K., Agari, T., Yasuhara, T., Morimoto, J., Okazaki, M., Takeuchi, H., Toyoshima, A., Sasada, S., Shinko, A., Kondo, A., Kameda, M., Miyazaki, I., Asanuma, M., Borlongan, C.V., Nishibori, M. and Date, I.
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Journal Title
Exp. Neurol.
Volume: 275
Pages: 220-231
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Perioperative Management Center (PERIO) for Neurosurgical Patients2016
Author(s)
Yasuhara T, Hishikawa T, Agari T, Kurozumi K, Ichikawa T, Kameda M, Shinko A, Ishida J, Hiramatsu M, Kobayashi M, Matsuoka Y, Sasaki T, Soga Y, Yamanaka R, Ashiwa T, Arioka A, Hashimoto Y, Misaki A, Ishihara Y, Sato M, Morimatsu H, Date I
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Journal Title
Neurologia medico-chirurgica
Volume: 56
Issue: 9
Pages: 574-579
DOI
NAID
ISSN
0470-8105, 1349-8029
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts neuroprotective effects in a transient ischemic stroke model in rats: Analyses of therapeutic time window and its mechanisms2015
Author(s)
Toyoshima A , Yasuhara T , Kameda M , Morimoto J , Takeuchi H , Wang F , Sasaki T , Sasada S , Shinko A , Wakamori T , Okazaki M , Kondo A , Agari T , Borlongan CV, Date I
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Journal Title
PLOS ONE
Volume: -
Issue: 6
Pages: e0127302-e0127302
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Spinal cord stimulation exerts neuroprotective effects against experimental Parkinson's disease2014
Author(s)
Shinko A, Agari T, Kameda M, Yasuhara T, Kondo A, Tayra JT, Sato K, Sasaki T, Sasada S, Takeuchi H, Wakamori T, Borlongan CV, Date I
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Journal Title
PLoS One
Volume: 9
Issue: 7
Pages: e101468-e101468
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 視床グリオーマの治療成績2016
Author(s)
黒住和彦、亀田雅博、石田穣治、市川智継、伊達 勲
Organizer
第34回日本脳腫瘍学会学術集会
Place of Presentation
甲府富士屋ホテル(甲府市)
Year and Date
2016-12-05
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[Presentation] Reoperation for posterior fossa lesion2016
Author(s)
Yasuhara T, Ichikawa T, Kurozumi K, Kameda M, Ishida J, Shinko A, Agari T, Hishikawa T, Date I
Organizer
28th Annual Meeting of Japanese Society for Skull Base Surgery・7th International Congress of the World Federation of Skull Base Societies
Place of Presentation
大阪国際会議場(大阪市北区)
Year and Date
2016-06-16
Related Report
Int'l Joint Research
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[Presentation] Hybrid microscopic-endoscopic surgery for craniopharyngioma2016
Author(s)
Ichikawa T, Otani Y, Ishida J, Kurozumi K, Kameda M, Date I
Organizer
28th Annual Meeting of Japanese Society for Skull Base Surgery・7th International Congress of the World Federation of Skull Base Societies
Place of Presentation
大阪国際会議場(大阪市北区)
Year and Date
2016-06-15
Related Report
Int'l Joint Research
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[Presentation] Electrical stimulation for the CNS diseases: from the aspect of regenerative medicine2016
Author(s)
Yasuhara T, Kameda M, Agari T, Takeuchi H, Morimoto J, Okazaki M, Kin K, Shinko A, Baba T, Morimoto T, Tajiri N, Date I
Organizer
2016 American Society for Neural Therapy and Repair
Place of Presentation
Tampa, U.S.A
Year and Date
2016-04-30
Related Report
Int'l Joint Research
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[Presentation] Encapsulated cell transplantation for central nervous system disorders2014
Author(s)
Yasuhara T, Kameda M, Agari T, Toyoshima A, Takeuchi H, Morimoto J, Kondo A, Shinko A, Sasada S, Sasaki T, Wakamori T, Okazaki M, Date I
Organizer
Society for Neuroscience 44th Annual Meeting 201
Place of Presentation
Washington, D.C. U.S.A
Year and Date
2014-11-19
Related Report
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[Presentation] Liraglutide exerts neuroprotective effects for cerebral infarct model of rats2014
Author(s)
Morimoto J , Sato K, Kameda M , Yasuhara T , Agari T , Baba T , Wang F , Wakamori T , Toyoshima A , Takeuchi H , Sasaki T , Sasada S , Borlongan CV , Matumae M , Date I
Organizer
Society for Neuroscience 44th Annual Meeting 201
Place of Presentation
Washington, D.C. U.S.A
Year and Date
2014-11-18
Related Report
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[Presentation] Neuroprotective effects of spinal cord stimulation on Parkinson's disease model of rats2014
Author(s)
Shinko A, Agari T, Yasuhara T, Kameda M, Kondo A, Sato K, Sasaki T, Sasada S, Toyoshima A, Takeuchi H, Date I
Organizer
Society for Neuroscience 44th Annual Meeting 201
Place of Presentation
Washington, D.C. U.S.A
Year and Date
2014-11-18
Related Report
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[Presentation] Anti-high mobility group box 1 antibody has neuroprotective effects against Parkinson's disease model of rats2014
Author(s)
Sasaki T , Agari T , Takeuchi H , Toyoshima A , Shinko A , Sasada S , Kondo A , Kameda M , Yasuhara T , Liu K, Nishibori M, Date I
Organizer
Society for Neuroscience 44th Annual Meeting 201
Place of Presentation
Washington, D.C. U.S.A
Year and Date
2014-11-16
Related Report
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