New approach for glioblastoma with immuno-chemotherapy using severe immunodeficiency mouse
Project/Area Number |
26861159
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Nara Medical University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 脳腫瘍 / 膠芽腫 / NK細胞 / γδT細胞 / temozolomide / 免疫療法 / bisphosphonate / NOGマウス / Bisphosphonate / テモゾロミド / ベバシズマブ |
Outline of Final Research Achievements |
Our aim to investigate is to establish the new approach for glioblastoma. We demonstrated that combination therapy with gamma delta T cell and bisphosphonate had a significant strong anti-tumor effect for transplanted glioblastoma cells into NOG mouse. In second experiment, we demonstrated that NK cells had a strong anti-tumor effect for temozolomide-resistant glioblastoma cells in vitro. In conclusion, gamma delta T cell and NK cells are promising cell source for glioblastoma.
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Report
(3 results)
Research Products
(5 results)
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[Presentation] 膠芽腫細胞株におけるミノドロン酸の抗腫瘍効果の検討.2015
Author(s)
中村光利, 中澤務, 松田良介, 朴永銖, 本山靖, 弘中康雄, 中川一郎, 西村文彦, 丸谷明子, 尾本幸治, 田中祥貴, 中瀬裕之
Organizer
第33回日本脳腫瘍学会学術総会
Place of Presentation
京都
Year and Date
2015-12-07
Related Report
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[Presentation] 膠芽腫細胞株におけるミノドロン酸の抗腫瘍効果の検討2015
Author(s)
丸谷明子, 中村光利, 松田良介, 西村文彦, 朴永銖, 本山靖, 弘中康雄, 中川一郎, 田村健太郎, 竹島靖浩 , 尾本幸治, 田中祥貴, 中瀬裕之
Organizer
第74回日本脳神経外科学会学術総会
Place of Presentation
札幌
Year and Date
2015-10-14
Related Report
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[Presentation] Minodronate exerts antitumor effects against human glioblastoma in cooperation with peripheral blood-derived γδ T cells2015
Author(s)
Tsutomu Nakazawa, Mitsutoshi Nakamura, Ryosuke Matsuda, Young Soo Park, Yasushi Motoyama, Yasuo Hironaka, Fumihiko Nishimura, Ichiro Nakagawa, Kentaro Tamura, Yasuhiro Takeshima, Akiko Marutani, Kouji Omoto, Yoshitaka Tanaka, Yukiteru Ouji, Masahide Yoshikawa, Takahiro Tsujimura, Hiroyuki Nakase
Organizer
International Conference of Cancer Immunotherapy and Macrophages 2015
Place of Presentation
東京
Year and Date
2015-07-09
Related Report
Int'l Joint Research
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