Role of angiotensin in thrombus formation by laser-induced cerebrovascular injury
| Project/Area Number |
26861162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳微小循環 / レーザー照射 / マウス / AT1受容体 / AT2受容体 |
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| Outline of Final Research Achievements |
Observation of thrombus formation after laser irradiation of murine pial arteries showed that effects of angiotensin Ⅱ type 1 (AT1) and type 2 (AT2) receptor on the process of thrombus formation and platelet behavior could be evaluated in vivo. The present study suggested that the laser-induced thrombus formation in murine pial arteries was inhibited by AT1 receptor deficiency, and was promoted by AT2 receptor deficiency.
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Report
(3 results)
Research Products
(1 results)
