Role of angiotensin in thrombus formation by laser-induced cerebrovascular injury

Research Project

Project/Area Number	26861162
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurosurgery
Research Institution	Saitama Medical University
Principal Investigator	MARUYAMA Hajime 埼玉医科大学, 医学部, 講師 (00646680)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	脳微小循環 / レーザー照射 / マウス / AT1受容体 / AT2受容体
Outline of Final Research Achievements	Observation of thrombus formation after laser irradiation of murine pial arteries showed that effects of angiotensin Ⅱ type 1 (AT1) and type 2 (AT2) receptor on the process of thrombus formation and platelet behavior could be evaluated in vivo. The present study suggested that the laser-induced thrombus formation in murine pial arteries was inhibited by AT1 receptor deficiency, and was promoted by AT2 receptor deficiency.