Analysis of metabloic characteristics of glioma stem cells
Project/Area Number |
26861168
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 幹細胞 / 癌 |
Outline of Final Research Achievements |
The objective of this study was to analyze the metabolic characteristics of glioma stem cells (GSCs) and identify related targetable factors. With the use of a mouse model of glioblastoma, we established GSCs that rely on glycolysis and GSCs that obtain energy mainly through the tricarboxylic acid cycle and investigated their metabolic characteristics. For each GSC fraction, we identified their preferential substrates and the enzymes supporting their metabolic profile. Furthermore, we showed that GSCs that can use the TCA cycle under normal conditions can flexibly switch to glycolysis in hypoxic conditions and that they display metabolic plasticity.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
Author(s)
Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H and Nagano O
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Journal Title
Cancer Res
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression2015
Author(s)
Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR and Chen CC
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Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 30
Pages: 112-130
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model2014
Author(s)
Saga I, Shibao S, Okubo J, Osuka S, Kobayashi Y, Yamada S, Fujita S, Urakami K, Kusuhara M, Yoshida K, Saya H, Sampetrean O
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Journal Title
Neuro Oncol.
Volume: 16
Issue: 8
Pages: 1048-1056
DOI
Related Report
Peer Reviewed / Open Access
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