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Identification of a novel epigenetic modifier in gliomagenesis

Research Project

Project/Area Number 26861172
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionNagoya University

Principal Investigator

Ohka Fumiharu  名古屋大学, 医学系研究科, 助教 (10725724)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経膠腫 / EZH2 / 脳腫瘍学 / 脳腫瘍マウスモデルの樹立
Outline of Final Research Achievements

In this study, we investigated the mechanisms of upregulated EZH2 in gliomagenesis. We already established a unique mouse model, which spontaneously develops glioma. Using this mouse model, we analyze the significance of EZH2 in gliomagenesis, sequentially. EZH2 is upregulated from an early stage of gliomagenesis, inducing accumulation of dysregulation of histone modification. We found that EZH2 plays pivotal roles with other histone modifier whose copy number of gene is amplified, cooperatively. Our data suggests that EZH2 might play pivotal roles in gliomagenesis via dysregulation of epigenetic alteration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Presentation] Epigenomic treatment for IDH wild-type grade III glioma, targeting dysregulation of EZH2-H3K27me32016

    • Author(s)
      Fumiharu Ohka, Atsushi Natsume, Hiromichi Suzuki, Kosuke Aoki, Shoichi Deguchi, Keisuke Katsushima, Keiko Shinjo, Toshihiko Wakabayashi, Yutaka Kondo
    • Organizer
      2016 SNO annual meeting
    • Place of Presentation
      米国アリゾナ州スコッツデール
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エピゲノム異常を誘導するEZH2を標的としたProneural GBMに対する新規治療戦略2015

    • Author(s)
      大岡史治 出口彰一 鈴木啓道 勝島啓佑 新城恵子 若林俊彦 近藤豊 夏目敦至
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都府京都市 グランドプリンスホテル京都
    • Year and Date
      2015-12-07
    • Related Report
      2015 Research-status Report
  • [Presentation] クロマチンダイナミクスを誘導するEZH2を標的とした膠芽腫の新規治療戦略2015

    • Author(s)
      大岡史治 出口彰一 鈴木啓道 勝島啓佑 新城恵子 若林俊彦 近藤豊 夏目敦至
    • Organizer
      日本脳神経外科学会第74回学術総会
    • Place of Presentation
      北海道札幌市 ロイトン札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Role of Dysregulation of EZH2-H3K27me3 in Gliomagenesis2015

    • Author(s)
      大岡史治 夏目敦至 出口彰一 勝島啓佑 新城恵子 若林俊彦 近藤豊
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市 名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 二次性膠芽腫マウスにおける経時的なクロマチンリモデリングによるエピゲノム変化2014

    • Author(s)
      大岡史治
    • Organizer
      第32回日本脳腫瘍学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイホテル(千葉県浦安市)
    • Year and Date
      2014-12-07 – 2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 膠芽腫の悪性転化に関わるエピゲノム異常を標的とした新規治療戦略の検討2014

    • Author(s)
      大岡史治
    • Organizer
      日本脳神経外科学会第73回学術総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] GBM形成に重要な役割を果たすエピゲノム異常の蓄積2014

    • Author(s)
      大岡史治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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