| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Synovial mesenchymal stem cells can be a useful cell source for articular cartilage regeneration. In this study, we analyzed the usefulness of synovial mesenchymal stem cell aggregates transplantation with microminipig.
Synovial mesenchymal stem cells derived from microminipigs had good colony forming ability, proliferative capacity and pluripotency. The aggregates were easy to handle, and it was easily transplanted in osteochondral defects. At 12 weeks after transplantation, cartilage regeneration in the transplanted group was better in both the macroscopic and histological scores than in the control group. In addition, it was confirmed by MRI analyses that the quality of regenerated cartilage in the transplanted group was closer to normal cartilage than in the control group.
According to this result, it is possible to transplant synovial mesenchymal stem cells more efficiently than conventional methods, which may contribute to improving clinical results.
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