Investigation of the effect of glycative stress on bone repair and development of new method of osteogenesis in diabetic patients

Research Project

Project/Area Number	26861176
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	Kanazawa University
Principal Investigator	Matsubara Hidenori 金沢大学, 医学系, 助教 (10507057)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	メチルグリオキサール / 糖化ストレス / 骨修復能
Outline of Final Research Achievements	In diabetic mice, the amount of AGEs in the serum and the femur significantly increased. In particular, methylglyoxal (MG)-derived AGEs were often found in the femur. Furthermore, MG plays a role in inhibiting the differentiation and proliferation of bone cells. In conclusions, MG was increased in diabetes mouse and acted directly to inhibit differentiation and proliferation of osteoblast resulting in delayed bone formation in diabetes. Therefore, activation of MG detoxification enzyme and administration of an MG scavenger is expected to improve bone repair.