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Investigation of the effect of glycative stress on bone repair and development of new method of osteogenesis in diabetic patients

Research Project

Project/Area Number 26861176
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKanazawa University

Principal Investigator

Matsubara Hidenori  金沢大学, 医学系, 助教 (10507057)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsメチルグリオキサール / 糖化ストレス / 骨修復能
Outline of Final Research Achievements

In diabetic mice, the amount of AGEs in the serum and the femur significantly increased. In particular, methylglyoxal (MG)-derived AGEs were often found in the femur. Furthermore, MG plays a role in inhibiting the differentiation and proliferation of bone cells. In conclusions, MG was increased in diabetes mouse and acted directly to inhibit differentiation and proliferation of osteoblast resulting in delayed bone formation in diabetes. Therefore, activation of MG detoxification enzyme and administration of an MG scavenger is expected to improve bone repair.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Bone repair is impaired in diabetes via an increased formation of methylglyoxal2016

    • Author(s)
      相川 敬男、松原 秀憲
    • Organizer
      American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting
    • Place of Presentation
      Orland (USA)
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糖尿病ではメチルグリオキサール産生による糖化ストレスの亢進によって骨修復能が低下する2015

    • Author(s)
      相川 敬男、松原 秀憲
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      富山市
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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